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Characterization of different types of epiretinal proliferations by synchrotron radiation-based Fourier transform infrared micro-spectroscopy [Elektronski vir]Andjelić, Sofija ...Pathological tissue on the surface of the retina that can be of different etiology and pathogenesis can cause changes in the retina that have a direct consequence on vision. Tissues of different ... etiology and pathogenesis have different morphological structures and also different macromolecule compositions usually characteristic of specific diseases. In this study, we evaluated and compared biochemical differences among samples of three different types of epiretinal proliferations: idiopathic epiretinal membrane (ERMi), membranes in proliferative vitreoretinopathy (PVRm), and proliferative diabetic retinopathy (PDRm). The membranes were analyzed by using synchrotron radiation-based Fourier transform infrared micro-spectroscopy (SR-FTIR). We used the SR-FTIR micro-spectroscopy setup, where measurements were set to achieve a high resolution that was capable of showing clear biochemical spectra in biological tissue. We were able to identify differences between PVRm, PDRm, and ERMi in protein and lipid structure; collagen content and collagen maturity; differences in proteoglycan presence; protein phosphorylation; and DNA expression. Collagen showed the strongest expression in PDRm, lower expression in ERMi, and very low expression in PVRm. We also demonstrated the presence of silicone oil (SO) or polydimethylsiloxane in the structure of PVRm after SO endotamponade. This finding suggests that SO, in addition to its many benefits as an important tool in vitreoretinal surgery, could be involved in PVRm formation.Vir: International journal of molecular sciences [Elektronski vir]. - ISSN 1422-0067 (Vol. 24, iss. 5, [article no.] 4834, 2023, 1-14 str.)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2023Jezik - angleškiCOBISS.SI-ID - 143961859
Avtor
Andjelić, Sofija |
Kreuzer, Martin |
Hawlina, Marko |
Lumi, Xhevat, 1962-
Teme
retina |
epiretinal membrane |
proliferative vitreoretinopathy |
proliferative diabetic retinopathy |
extracellular matrix |
macromolecule analysis |
oxidative stress |
synchrotron radiation-based Fourier transform infrared micro-spectroscopy |
mrežnica |
epiretinalna membrana |
proliferativna vitreoretinopatija |
proliferativna diabetična retinopatija |
zunajcelični matriks |
analiza makromolekul |
oksidativni stres |
Fourier na osnovi sinhrotronskega sevanja transformira infrardečo mikrospektroskopijo
Vnos na polico
Trajna povezava
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Andjelić, Sofija | 28627 |
Kreuzer, Martin | |
Hawlina, Marko | 09154 |
Lumi, Xhevat, 1962- | 35744 |
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