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  • The influence of pilocarpine and biperiden on pH value and calcium, phosphate, and bicarbonate concentrations in saliva during and after radiotherapy for head and neck cancer
    Rode, Mirela ...
    Objective. The purpose of the present study was to investigate the influence of parasympathomimetic pilocarpine and anticholinergic biperiden on salivation, pH value, and calcium, phosphate, and ... bicarbonate concentrations in saliva in patients irradiated for malignant tumors of the head and neck region. Study design. Sixty-nine patients were randomly assigned into 3 groups. Group A consisted of patients receiving pilocarpine, group B of those who were receiving biperiden during radiotherapy and pilocarpine for 6 weeks after its completion, and group C comprised patients receiving neither of the mentioned drugs. The quantity of secreted unstimulated saliva, its pH value, as well as calcium, phosphate, and bicarbonate concentrations in saliva were measured before the beginning oi radiutherapy, after 30 Gy of irradiation, at completed irradiation, and 3, 6, and 12 months after completion of radiotherapy. Results. Saliva secretion was found to be the least affected in the group of patients receiving biperidene throughout the course of radiotherapy. One year after completion of therapy, the quantity of secreted saliva could only be measured in the patientž receiving biperiden during radiotherapy; it amounted to 16% of the average initial quantity of saliva secreted before the beginning of irradiation. In all 3 groups of patients, mean pH value decreased during radiotherapy and started to increase again aiter completion of irradiation. In group B the decrease in pH value after radiotherapy was statistically significantly smaller than that in group C (P= .01). During and after irradiation, calcium concentration was increased in all3 groups of patients. Phosphate concentration decreased during radiotherapyin all 3 groups. In group B it started to increase again 3 months after completion of radiotherapy. (Abstract truncated at 2000 characters).
    Vir: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. - ISSN 1079-2104 (Letn. 92, 2001, str. 509-514)
    Vrsta gradiva - članek, sestavni del
    Leto - 2001
    Jezik - angleški
    COBISS.SI-ID - 14610649

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