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13.
The contribution of HLA-DQB1 coding and QBP promoter alleles to anti-Ro alone autoantibody response in systemic lupus erythematosus
Logar, Dušan, 1951- ...
Objective. To analyse the influence of HLA-DR, DQ and corresponding DQAI and DQBI promoter alleles (QAP and QBP) on the anti-Ro alone autoantibody responsein systemic lupus erythematosus (SLE). ...Methods. Sixty-five unrelated anti-La antibody-negative SLE patients, 37 of them with and 28 without anti-Roantibodies, were included. Anti-Ro antibodies were determined by both counter-immunoelectrophoresis and enzyme-linked immunosorbent assay. Seventy-four healthy individuals were selected as controls. The patients and controls were analysed for HLA-DRBI , QAP, DQA1, QBP and DQBl alleles by DNA typing. The allelic frequencies of anti-Ro alone-positive and anti-Ro-negativeSLE patients and healthy controls were compared using the x2 test or Fisher's exact test as appropriate. Results. The DQB1*0202 allele showed a significant positive correlation with anti-Ro alone antibodies (odds ratio (OR) = 16.949, P = 0:0015, corrected P - 0.018), while the QBP5.11 allele and the combination of DQB1*0301 and its promoter QBP3.1 were under-represented in anti-Ro-alone-positive SLE patients (P = 0.01, corrected P = 0.048 and corrected P = 0.048 respectively). Conclusions. The above-mentioned alleles may contribute to the presence or absence of anti-Ro alone autoantibodies in SLE patients.
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