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An EORTC phase I study of epirubicin in combination with fixed doses of cyclophosphamide and infusional 5-fu (CEF-infu) as primary treatment of large operable or locally advanced/inflammatory breast cancerBonnefoi, H... ...PURPOSE: The association of continuous infusion 5-fluorouracil, epirubicin (50mg/m2 q 3 weeks) and a platinum compound (cisplatin or carboplatin) was found to be very active in patients with either ... locally advanced/inflammatory (LA/I) (1, 2) or large operable (LO) breast cancer (BC) (3). The same rate of activity in terms of response rate (RR) and response duration was observed in LA/I BC patients when cisplatin was replaced by cyclophosphamide (4). The doseof epirubicin was either 50 mg/m2 (1, 2, 3) or 60 mg/m2/cycle (4). The main objective of this study was to determine the maximum tolerated dose (MTD)of epirubicin when given in combination with fixed doses of cyclophosphamide and infusional 5-fluorouracil (CEF-infu) as neoadjuvant therapy in patients with LO or LA/I BC for a maximum of 6 cycles. PATIENTS ANDMETHODS: Eligible patients had LO or LA/I BC, a performance status 0-1, adequate organ function and were <65 years old. Cyclophosphamide was administered at the dose of 400 mg/m2 day 1 and 8, q 4 weeks and infusional 5-fluorouracil 200 mg/m2/day was given day 1-28, q 4 weeks. Epirubicin was escalated from 30 to 45 and to 60 mg/m2 day 1 and 8; dose escalation was permitted if 0/3 or 1/6 patients experienced dose limiting toxicity (DLT) during the first 2 cycles of therapy. DLT for epirubicin was defined as febrile neutropenia, grade 4 neutropenia lasting for >7 days, grade 4 thrombocytopenia, or any non-haematological toxicity of CTC grade > or =3, excluding alopecia and plantar-palmar erythrodysesthesia (this toxicity was attributable to infusional 5-fluorouracil and was not considered a DLT of epirubicin). RESULTS: A total of 21 patients, median age 44 years (range 29-63) have been treated. 107 courses have been delivered, with a median number of 5 cycles per patient (range 4-6). DLTs on cycles 1 and 2 on level 1,2, 3: grade 3 (G3) mucositis occurred in 1/10 patients treated at the third dose levelVir: Breast cancer research and treatment. - ISSN 0167-6806 (Letn. 70, št. 1, 2001, str. 55-63)Vrsta gradiva - članek, sestavni delLeto - 2001Jezik - angleškiCOBISS.SI-ID - 14897625
Avtor
Bonnefoi, H... |
Biganzoli, L... |
Čufer, Tanja, 1955- |
Mauriac, L... |
Hamilton, A... |
Schaefer, P... |
Picart, M...
Teme
Breast neoplasms |
Drug therapy |
Epirubicin |
Cyclophosphamide |
Fluorouracil |
Treatment outcome |
Neutropenia |
Neoplasm staging |
Thrombocytopenia |
Alopecia |
Ciklofosfamid |
Dojka, novotvorbe |
Epirubicin |
Fluorouracil |
Alopecija |
Izid zdravljenja |
Nevtropenija |
Novotvorba, stadij |
Trombocitopenija
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Čufer, Tanja, 1955- | 12179 |
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