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Development of nanofibers with embedded liposomes containing an immunomodulatory drug using green electrospinning [Elektronski vir]Casula, Luca ...Conventional treatments for chronic wounds are often ineffective, thus new therapeutic approaches are needed, such as the delivery of immunomodulatory drugs that can reduce inflammation, restore ... immune cell function, and facilitate tissue regeneration. A potential drug for such an approach is simvastatin, which has major drawbacks including poor solubility and chemical instability. With the aim of developing a dressing for wound healing, simvastatin and an antioxidant were incorporated into alginate/poly(ethylene oxide) nanofibers by green electrospinning without the use of organic solvents, thanks to their prior encapsulation into liposomes. The composite liposome–nanofiber formulations exhibited fibrillar morphology (160–312 nm) and unprecedentedly high phospholipid and drug content (76%). Transmission electron microscopy revealed dried liposomes as bright ellipsoidal spots homogeneously distributed over the nanofibers. After nanofiber hydration, the liposomes reconstituted in two size populations (~140 and ~435 nm), as revealed by cutting-edge MADLS® analysis. Lastly, in vitro assays demonstrated that composite liposome–nanofiber formulations are superior to liposomal formulations due to a better safety profile in keratinocytes and peripheral blood mononuclear cells. Furthermore, both formulations exhibited similarly advantageous immunomodulatory effects, measured as decreased inflammation in vitro. A synergistic combination of the two nanodelivery systems shows promise for the development of efficient dressings for chronic wound treatment.Vir: Pharmaceutics [Elektronski vir]. - ISSN 1999-4923 (Vol. 15, iss. 4, art. 1245, 2023, 19 str.)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2023Jezik - angleškiCOBISS.SI-ID - 149379587
Avtor
Casula, Luca |
Zidar, Anže |
Kristl, Julijana |
Jeras, Matjaž |
Kralj, Slavko, 1983- |
Fadda, Anna Maria |
Zupančič, Špela, farmacevtka
Teme
Imunomodulacija |
Nanovlakna |
simvastatin |
liposomi v nanovlaknih |
zeleno elektropredenje |
imunomodulacija |
obloga za rane |
alginat |
transmisijska elektronska mikroskopija |
večkotno dinamično sipanje svetlobe |
varnost in vitro |
simvastatin |
liposomes in nanofibers |
green electrospinning |
immunomodulation |
wound dressing |
alginate |
TEM |
MADLS analysis |
in vitro safety
Avtor | Casula, Luca ... |
Naslov | Development of nanofibers with embedded liposomes containing an immunomodulatory drug using green electrospinning [Elektronski vir] |
Datum objave | 2023-04-14 |
COBISS.SI-ID | 149379587 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
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Nanozdravila z antibiotiki in probiotiki za lokalno zdravljenje parodontalne bolezni | J1-9194-2018 |
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Izkoriščanje magneto-mehanskega učinka pri zdravljenju nevrodegenerativnih bolezni | J2-3043-2021 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Nanovlakna za sočasno dostavo koktajlov izbrane mikrobiote in protimikrobnih učinkovin za lokalno zdravljenje vaginalnih infekcij | J7-4418 | ||
UniCA- Progetti biennali d’Ateneo | CUPF73C22001170007 |
Datoteke, ki spadajo k objavi
Povezava |
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https://www.mdpi.com/1999-4923/15/4/1245 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=145335 |
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Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Casula, Luca | |
Zidar, Anže | 53870 |
Kristl, Julijana | 09032 |
Jeras, Matjaž | 01302 |
Kralj, Slavko, 1983- | 29529 |
Fadda, Anna Maria | |
Zupančič, Špela, farmacevtka | 36439 |
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