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Role of cascades in converting oscillatory signals into stationary step-like responsesMarhl, Marko ; Grubelnik, VladimirIn biological signal transduction pathways intermediates are often oscillatory and need to be converted into smooth output signals at the end. We show by mathematical modelling that protein kinase ... cascades enable converting oscillatory signals into sharp stationary step-like outputs. The importance of this result is demonstrated for the switch-like protein activation by calcium oscillations, which is of biological importance for regulating different cellular processes. In addition, we found that protein kinase cascades cause memory effects in the protein activation, which might be of a physiological advantage since a smaller amount of calcium transported in the cell is required for an effective activation of cellular processes.Vir: Biosystems. - ISSN 0303-2647 (Vol. 87, iss. 1, jan. 2007, str. 58-67)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2007Jezik - angleškiCOBISS.SI-ID - 15160584
Avtor
Marhl, Marko |
Grubelnik, Vladimir
Teme
fizika |
matematično modeliranje |
kalcijeve oscilacije |
kalcij |
signalne kaskade |
protein kinaza |
celična dinamika |
signalna ransdukcija |
biokemijsko preklapljanje |
physics |
calcium oscillations |
mathematical modelling |
calcium |
calcium oscillations |
sygnalling cascade |
protein kinase cascades |
signal transduction |
ultrasensitivity |
biochemical switch |
cellular dynamics
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Grubelnik, Vladimir | 21816 |
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