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  • Role of cascades in converting oscillatory signals into stationary step-like responses
    Marhl, Marko ; Grubelnik, Vladimir
    In biological signal transduction pathways intermediates are often oscillatory and need to be converted into smooth output signals at the end. We show by mathematical modelling that protein kinase ... cascades enable converting oscillatory signals into sharp stationary step-like outputs. The importance of this result is demonstrated for the switch-like protein activation by calcium oscillations, which is of biological importance for regulating different cellular processes. In addition, we found that protein kinase cascades cause memory effects in the protein activation, which might be of a physiological advantage since a smaller amount of calcium transported in the cell is required for an effective activation of cellular processes.
    Vir: Biosystems. - ISSN 0303-2647 (Vol. 87, iss. 1, jan. 2007, str. 58-67)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2007
    Jezik - angleški
    COBISS.SI-ID - 15160584

vir: Biosystems. - ISSN 0303-2647 (Vol. 87, iss. 1, jan. 2007, str. 58-67)
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