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  • Xylan modification for hemocompatibility achievement
    Strnad, Simona, 1965- ...
    Xylans are second most important substance of cell wall beside cellulose and largest source of sustainable hemicellulose on the Earth. Xylans from different plant sources have shown promising ... immunostimulating activities. Enzymatically modified xylans from rice husks showed high anti-HIV activity without side effects [1]. The development of haemocompatible biomaterials represents extreme challenge, thus the cardiovascular complications are a main reason of deaths in developed world. Conventional anticoagulant heparin is derived from animal source and as such represents potential risk for patients. For that reason, the research is focused in searching of novel antithrombotic substances of plant sources. The main goal of this study was to chemically modify xylans from different sources, to introduce antithromboticproperties as a novel coating substance for biomedical use. The results showed that the applied procedure of sulphation was appropriate for chosen xylan samples. Sulphate groups were successfully introduced to polymer chemical structure (app. 1.5 mmol of sulphate groups per g of sample). Activated partial thromboplastin time (APTT) increased after sulphation in comparison to non- sulphated samples, and xylan samples became water soluble and as such suitable for bioactive functionalization of biomedical polymer surfaces.
    Vir: IN-TECH 2011 : proceedings (Str. 539-541)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2011
    Jezik - angleški
    COBISS.SI-ID - 15311638

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