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Expression of cysteine peptidase cathepsin L and its inhibitors stefins A and B in relation to tumorigenicity of breast cancer cell linesZajc, Irena ...The in vitro invasiveness of human breast cancer cell lines was compared with their reported tumorigenicity in vivo, increasing from MCF7, MDA-MB468, MDA-MB231 to MDA-MB435 cells. The invasiveness ... roughly corresponded to the tumorigenicity of the cell lines. The levels of eathepsin L mRNA and protein correlated with the invasiveness of the cells. Stefin A protein decreased withthe invasiveness and the reported tumorigenicity, whereas stefin B proteinwas significantly lower in all MDA-MB lines compared with the least invasive and tumorigenic MCF7 line. Our results suggest that the imbalance between cathepsin L and the stefins contributes to the development of a malignant cell phenotype.Vir: Cancer letters. - ISSN 0304-3835 (Letn. 187, št. 1/2, December 2002, str. 185-190)Vrsta gradiva - članek, sestavni delLeto - 2002Jezik - angleškiCOBISS.SI-ID - 15633881
Avtor
Zajc, Irena |
Sever, Nataša |
Bervar, Aleš |
Lah Turnšek, Tamara
Teme
Breast Neoplasms |
Tumor Cells, Cultured |
Drug Effects |
Cathepsins |
Cysteine Proteinase Inhibitors |
Neoplasm Invasiveness |
Rna, Messenger |
Cistenska proteinaza, inhibitorji |
Dojka, novotvorbe |
Katepsini |
Novotvorba, invazivnost |
Tumorske celične kulture |
RNA, prenašalna
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Zajc, Irena | 10974 |
Sever, Nataša | 16193 |
Bervar, Aleš | 18466 |
Lah Turnšek, Tamara | 07802 |
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