-
DNA damage distribution in the human brain as shown by in situ end labeling : area-spe differences in aging and alzheimer disease in the absence of apoptotic morphologyLucassen, Paul J. ...DNA damage has been proposed to underlie neuronal degeneration in aging and Alzheimer disease (AD). To determine the histological distribution of DNA damage, in situ end labeling (ISEL) was applied ... as a marker for DNA breaks on 4 differentially affected brain areas. Occipital cortex showed considerable variation between cortical layers and between patients. Temporal cortex displayed little ISEL-Iabeling in controls, and in AD, surprisingly. In the hippocampus, which is strongly affected in AD, many ISEL-positive nuclei and glialike cells were found in AD as compared with controls. The hypothalamic supraoptic and paraventricular nuclei showed little DNA-damage, whereas the nucleus basalis was often, but not always, labeled by ISEL. In contrast to others, no apoptotic morphology was observed, only necrotic morphology. Our results in relation to postmortem delay indicate that, area dependent, increased DNA vulnerability may occur in AD. Furthermore, the distribution of DNA damage in cortex differs from that of plaques and tangles, suggesting that these 3 phenomena are, in principle, independent. Whether the enhanced level of hippocampal DNA breaks in AD underlies, or rather is a consequence of, previous degenerative changes in this brain area remains to be established.Vir: Journal of neuropathology and experimental neurology. - ISSN 0022-3069 (Vol. 56, iss. 8, 1997, str. 887-900)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 1997Jezik - angleškiCOBISS.SI-ID - 157397763
Avtor
Lucassen, Paul J. |
Chung, Wilson Chee Jen |
Kamphorst, Wouter |
Swaab, Dick Frans |
Verhaagen, Joost
Teme
Alzheimer disease |
apoptosis |
DNA damage |
hippocampus |
hypothalamus |
necrosis |
postmortem delay |
Alzheimerjeva bolezen |
apoptoza |
poškodbe DNA |
hipokampus |
hipotalamus |
nekroza |
postmortalna zamuda
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Lucassen, Paul J. | ![]() |
Chung, Wilson Chee Jen | ![]() |
Kamphorst, Wouter | ![]() |
Swaab, Dick Frans | 52101 |
Verhaagen, Joost | ![]() |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.