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The effect of polymeric binder type and concentration on flow and dissolution properties of SMEDDS loaded mesoporous silica-based granulesKovačević, Mila ; Zvonar Pobirk, Alenka, 1980- ; German Ilić, Ilija, farmacevtSelf-microemulsifying drug delivery systems (SMEDDS) are lipid-based formulations, designed to improve the solubility of poorly-water soluble drugs. Mesoporous silica is frequently used for SMEDDS ... solidification by various techniques. One of them is wet granulation, which enables achieving both high SMEDDS load and good flow properties. This study investigated the effect of six polymeric binders’ addition to granulation dispersion (GD) (povidone K30, povidone K90, copovidone, Pharmacoat® 603, Pharmacoat® 615 and MethocelTM K100 Premium LV) on characteristics of produced SMEDDS granules, prepared by wet granulation. By incorporation of polymer in GD, it was possible to produce mesoporous silica-based free-flowing granules, with preserved self-microemulsifying properties, responsible for improved in vitro release of carvedilol. The incorporation of higher molecular weight binders resulted in slower in vitro release, while high binder concentration was related to faster drug release. The highest release rate was achieved with povidone K30 at 7.45 % binder concentration, as corresponding granules exhibited complete drug release already in 5 minutes. Granulation method (manual vs. high-shear) influenced the release rate of carvedilol as it was released slower from SMEDDS granules prepared using the granulator. Finally, SMEDDS tablet formulation was optimized to achieve maximum granule content and adequate tablet hardness. Increased granule content found to negatively influence tablet hardness, as maximum granule content of 25 % was needed to obtain appropriate hardness. Such tablets exhibited short disintegration time, so this final prototype can be considered as orodispersible tablet.Vir: European Journal of Pharmaceutical Sciences. - ISSN 0928-0987 (Vol. 193, 2024, 11 str.)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2024Jezik - angleškiCOBISS.SI-ID - 169225987
Avtor
Kovačević, Mila |
Zvonar Pobirk, Alenka, 1980- |
German Ilić, Ilija, farmacevt
Teme
Farmacevtska tehnologija |
Topnost |
SMEDDS |
high-shear granulation |
mesoporous carrier |
polymeric binder |
SMEDDS tablets |
SMEDDS |
granulacija z visokim strigom |
mezoporozni nosilec |
polimerno vezivo |
tablete SMEDDS
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Kovačević, Mila | ![]() |
Zvonar Pobirk, Alenka, 1980- | 26226 |
German Ilić, Ilija, farmacevt | 28446 |
Vir: Osebne bibliografije
in: SICRIS
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