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  • Moderate intensity exercise reduces side effects of cancer therapy and maintains cardiorespiratory fitness in male breast cancer patients : findings from the BRECA male crossover study
    Schultz, Eva B. ...
    Introduction There is growing evidence that exercise mitigates cancer therapy-related side-effects and improves cardiorespiratory fitness (CRF). However, in our knowledge, no exercise study has been ... conducted in male breast cancer (MBC) patients. The aim of the present study was to investigate the feasibility and efficacy of different exercise intensities on CRF and self-reported questionnaire items in MBC patients. Methods Twenty-two MBC patients (60±9 years) participated in this randomized cross-over study. After completion of medical treatment, MBC patients were randomly assigned to either moderate (40-50% of HR max. and self-perceived exertion: 11) or vigorous (70-80% of HR max. and self-perceived exertion:15) exercise intensity during the first three months of the study. After a one-month washout period, participants switched group assignments. Primary endpoints were CRF and questionnaire items. Results We observed a dropout rate of 36% over 7 months, with the number of participants decreasing from 22 to 14. The results showed significant improvements in "Physical Function" (p=0.037) and "Social Function" (p=0.016) after moderate training. A non-significant improvement was also observed in "Breast Symptoms" (p=0.095), but there was no change in "Fatigue" (p=0.306). There were no differences observed in cardiovascular fitness (V̇O2 peak) between the treatment groups. Conclusion We show, for the first time that exercise intervention is feasible and effective in patients with a very rare cancer. Apparently, moderate-intensity exercise mitigates many of the side effects of cancer treatment, whereas no differences between peak V̇O2 suggest that both exercise protocols are suitable for maintaining CRF. Further studies are warranted to develop optimized sex-specific rehabilitation protocols for MBC patients.
    Vir: Breast care. - ISSN 1661-3791 (Vol. [Online First], no. [Online First], 2023, 18 str.)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 170952963

    Povezava(-e):

    https://doi.org/10.1159/000534090
    DOI

vir: Breast care. - ISSN 1661-3791 (Vol. [Online First], no. [Online First], 2023, 18 str.)
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