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  • NMR relaxometric properties and cytotoxicity of $\rm{Gd_2O_3}$ nanoparticle suspensions in an organic liquid
    Babić-Stojić, Branka ...
    ▫$\rm{Gd_2O_3}$▫ nanoparticles and their agglomerates from approximately 10 to 80 nm in size suspended in an organic liquid were synthesized via polyol route. The reaction between diethylene glycol ... and added acetic acid, which occurred simultaneously with the synthesis of ▫$\rm{Gd_2O_3}$▫ nanoparticles, was catalyzed by sodium bisulfate to transform as much as possible diethylene glycol in corresponding ester at the end of complete reaction. The produced nanosized material of gadolinium oxide was investigated by TEM, DLS, FTIR spectroscopy, and NMR relaxometry. Biological evaluation of this material was done by MTT and crystal violet assays to determine the cell viability. Longitudinal and transverse relaxivities of water-diluted ▫$\rm{Gd_2O_3}$▫ nanoparticle suspensions estimated to be ▫$r_1 = 13.6$▫ and ▫$r_2 = 14.7$▫ ▫$\rm{s^{-1} \; mM^{-1}}$▫ are about three times higher compared to the relaxivities obtained for standard contrast agent Gd-DTPA (Magnevist). Good MRI signal intensities of the water-diluted ▫$\rm{Gd_2O_3}$▫ nanoparticle suspensions were recorded in the Gd concentration range 0.2-0.3 mM for which the suspensions were not toxic exhibiting simultaneously higher signal intensities than those for Magnevist in the Gd concentration range 0.4-1 mM for which this standard contrast agent was not toxic. These properties make the produced ▫$\rm{Gd_2O_3}$▫ nanoparticle material promising for potential application as MRI contrast agent.
    Vir: Journal of nanoparticle research. - ISSN 1388-0764 (Vol. 16, iss. 10, 2014, Art. 2663 (str. 1-11))
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 17211481

    Povezava(-e):

    http://dx.doi.org/10.1007/s11051-014-2663-0

vir: Journal of nanoparticle research. - ISSN 1388-0764 (Vol. 16, iss. 10, 2014, Art. 2663 (str. 1-11))
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