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Emerging prognostic and predictive significance of stress keratin 17 in HPV-associated and non HPV-associated human cancers [Elektronski vir] : a scoping reviewLožar, Taja ...A growing body of literature suggests that the expression of cytokeratin 17 (K17) correlates with inferior clinical outcomes across various cancer types. In this scoping review, we aimed to review ... and map the available clinical evidence of the prognostic and predictive value of K17 in human cancers. PubMed, Web of Science, Embase (via Scopus), Cochrane Central Register of Controlled Trials, and Google Scholar were searched for studies of K17 expression in human cancers. Eligible studies were peer-reviewed, published in English, presented original data, and directly evaluated the association between K17 and clinical outcomes in human cancers. Of the 1705 studies identified in our search, 58 studies met criteria for inclusion. Studies assessed the prognostic significance (n = 54), predictive significance (n = 2), or both the prognostic and predictive significance (n = 2). Altogether, 11 studies (19.0%) investigated the clinical relevance of K17 in cancers with a known etiologic association to HPV; of those, 8 (13.8%) were focused on head and neck squamous cell carcinoma (HNSCC), and 3 (5.1%) were focused on cervical squamous cell carcinoma (SCC). To date, HNSCC, as well as triple-negative breast cancer (TNBC) and pancreatic cancer, were the most frequently studied cancer types. K17 had prognostic significance in 16/17 investigated cancer types and 43/56 studies. Our analysis suggests that K17 is a negative prognostic factor in the majority of studied cancer types, including HPV-associated types such as HNSCC and cervical cancer (13/17), and a positive prognostic factor in 2/17 studied cancer types (urothelial carcinoma of the upper urinary tract and breast cancer). In three out of four predictive studies, K17 was a negative predictive factor for chemotherapy and immune checkpoint blockade therapy response.Vir: Viruses [Elektronski vir]. - ISSN 1999-4915 (Vol. 15, iss. 12, 2023, str. 2320-1-2320-22)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2023Jezik - angleškiCOBISS.SI-ID - 174584835
Avtor
Ložar, Taja |
Gavrielatou, Niki |
Christensen, Leslie |
Lambert, Paul F. |
Harari, Paul M. |
Rimm, David L. |
Burtness, Barbara |
Grašič-Kuhar, Cvetka |
Wang, Wei, 1957 March 10- |
Carchman, Evie H.
Teme
biološki označevalci |
citokeratin 17 |
rak glave in vratu |
imunski zaviralci nadzornih točk |
biomarker validation |
cytokeratin 17 |
head and neck cancer |
immune check-point inhibitors
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Ložar, Taja | ![]() |
Gavrielatou, Niki | ![]() |
Christensen, Leslie | ![]() |
Lambert, Paul F. | ![]() |
Harari, Paul M. | ![]() |
Rimm, David L. | ![]() |
Burtness, Barbara | ![]() |
Grašič-Kuhar, Cvetka | 15875 |
Wang, Wei, 1957 March 10- | ![]() |
Carchman, Evie H. | ![]() |
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