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Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human healthLouro, Henriqueta ...Fungi of the genus Alternaria are ubiquitous plant pathogens and saprophytes which are able to grow under varying temperature and moisture conditions as well as on a large range of substrates. A ... spectrum of structurally diverse secondary metabolites with toxic potential has been identified, but occurrence and relative proportion of the different metabolites in complex mixtures depend on strain, substrate, and growth conditions. This review compiles the available knowledge on hazard identification and characterization of Alternaria toxins. Alternariol (AOH), its monomethylether AME and the perylene quinones altertoxin I (ATX-I), ATX-II, ATX-III, alterperylenol (ALP), and stemphyltoxin III (STTX-III) showed in vitro genotoxic and mutagenic properties. Of all identified Alternaria toxins, the epoxide-bearing analogs ATX-II, ATX-III, and STTX-III show the highest cytotoxic, genotoxic, and mutagenic potential in vitro. Under hormone-sensitive conditions, AOH and AME act as moderate xenoestrogens, but in silico modeling predicts further Alternaria toxins as potential estrogenic factors. Recent studies indicate also an immunosuppressive role of AOH and ATX-II; however, no data are available for the majority of Alternaria toxins. Overall, hazard characterization of Alternaria toxins focused, so far, primarily on the commercially available dibenzo-α-pyrones AOH and AME and tenuazonic acid (TeA). Limited data sets are available for altersetin (ALS), altenuene (ALT), and tentoxin (TEN). The occurrence and toxicological relevance of perylene quinone-based Alternaria toxins still remain to be fully elucidated. We identified data gaps on hazard identification and characterization crucial to improve risk assessment of Alternaria mycotoxins for consumers and occupationally exposed workers.Vir: Archives of toxicology. - ISSN 0340-5761 (Vol. 98, 2024, str. 425-469)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2024Jezik - angleškiCOBISS.SI-ID - 179507203
Avtor
Louro, Henriqueta |
Vettorazzi, Ariane |
López de Cerain, Adela |
Žegura, Bojana |
Novak, Matjaž, biologija, 1987-
Teme
mycotoxin |
exposure routes |
genotoxicity |
endocrine disruption |
immunosuppression |
biotransformation |
toxicokinetics |
tenuazonic acid |
alternariol |
altenuene |
tentoxin |
altertoxin
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Avtor | Louro, Henriqueta ... |
Naslov | Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health |
Datum objave | 2024-01-01 |
COBISS.SI-ID | 179507203 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
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Partnership for the Assessment of Risks from Chemicals | PARC | 101057014 |
European Commission |
Datoteke, ki spadajo k objavi
Povezava |
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Louro, Henriqueta | ![]() |
Vettorazzi, Ariane | ![]() |
López de Cerain, Adela | ![]() |
Žegura, Bojana | 20767 |
Novak, Matjaž, biologija, 1987- | 34200 |
Vir: Osebne bibliografije
in: SICRIS
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