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  • Effectiveness of Helicobacter pylori treatments according to antibiotic resistance
    Bujanda Fernández de Piérola, Luis ...
    Background aims: Antibiotic resistance is one of the main factors that determines the efficacy of treatments to eradicate Helicobacter pylori (H. pylori) infection. Our aim was to evaluate the ... effectiveness of first-line and rescue treatments against H. pylori in Europe according to antibiotics resistance. Methods: Prospective, multicenter, international registry on the management of H. pylori (Hp-EuReg). All infected and culture-diagnosed adult patients registered in AEG-REDCap e-CRD from 2013-2021 were included. Results: A total of 2,852 naïve patients with culture results were analyzed. Resistance to clarithromycin, metronidazole and quinolones was 22%, 27% and 18%, respectively. The most effective treatment, regardless of resistance, were the three-in-one single-capsule with bismuth, metronidazole and tetracycline (96%), and the classic bismuth quadruple, offering optimal cure rates even in the presence of bacterial resistance to clarithromycin or metronidazole. The concomitant regimen with tinidazole achieved an eradication rate of 100% (68/68) vs. 73% (44/60) with metronidazole. Triple schedules, sequential or concomitant regimen with metronidazole did not achieve optimal results.A total of 1,118 non-naïve patients were analyzed. Resistance to clarithromycin, metronidazole and quinolones was 49%, 41% and 24%, respectively. The three-in-one single-capsule (87%) and the triple therapy with levofloxacin (85%) were the only ones that provided encouraging results. Conclusions: In regions where the antibiotic resistance rate of H. pylori is high, eradication treatment with the three-in-one single-capsule, the quadruple with bismuth and concomitant with tinidazole are the best options in naïve patients. In non-naïve patients, the three-in-one single-capsule and the triple therapy with levofloxacin provided encouraging results.
    Vir: The American journal of gastroenterology. - ISSN 0002-9270 (Vol. , iss. , Oct. 2023, str.)
    Vrsta gradiva - članek, sestavni del
    Leto - 2023
    Jezik - angleški
    COBISS.SI-ID - 180479235

    Povezava(-e):

    https://pubmed.ncbi.nlm.nih.gov/37983769/
    DOI

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