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  • Pooled analysis of prognostic impact of uPA and PAI-I in breast cancer patients
    Look, Maxime ...
    In this report we present an extension of the pooled analysis of the prognostic impact of urokinase-type plasminogen acdvator (uPA) and its inhibitor PA!-I in breast rancer patients. We analyzed a ... different endpoint, metastasis-free survival (MFS). We checked the consistency of the estimates for uPA and PAI-I for relapse-free survival (RFS) and MFS exploring possible sources of heterogeneity. Nodal status, the most important prognostic factor for breast cancer, introduced heterogeneity in the uPAIPAI-I survival analyses, reflecting the interaction between nodal status and uPAIPAI-I.The estimates for uPA and PAI-I were found to be consistent, even when a differenttransforma- , tion of their values was used. The heterogeneity of theseparate data sets decreased if the levels of uPA and PAI-I were ranked, data sets were pooled, and the analyses corrected for the base model that included all traditional prognostic factors, and stratified by data set. We conclude that uPA and PAI-I are ready to be used in the clinic to help classify breast cancer patients into high and low risk groups.
    Vir: Thrombosis and haemostasis. - ISSN 0340-6245 (Letn. 90, 2003, str. 538-548)
    Vrsta gradiva - članek, sestavni del
    Leto - 2003
    Jezik - angleški
    COBISS.SI-ID - 18176985

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