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13.
Tumorska imunologija - od poskusov do klinične uporabe = Tumor immunology - from experiment to clinical application
Jurin, Mislav
By using a modified colony inhibition test a specific immune reaction of tumorbearing mouse was proven. The intensity of lymphocyte cytotoxicity, determined in vitr-o, increased during an initial ...phase of tumor growth what was followed with a decrease. Sera fomr tumor bearing mice were able to specifically block the cytotoxic action of lymphocytes against tumor cells in vitro. These dynamics of specific immune response in tumor bearing mice duringtumor progression, i. e. the increase and decrease, are very similar to those of general immune reactivity. However, if local tumor was removed (irradiation or surgery) the recovery of immune reactivity occurred. Namely, the cytotoxic action of lymphocytes from cured mice was very pronounced and the sera were not able to block the reaction. The general immune reactivity also recovered following tumor removal. It was, further, shown that the application of an immunomodulator (particular extracts from plants and animals) could increase the immune reactivity in tumor bearing mice. All theseexperimental data were the base for our approach to the clinic. The monitoring of the immune reaction was performed in ovarian carcinoma patients grade III treated with chemotherapy. They were further treated with an immunomodulator. Thus, two weeks after one chemotherapy procedure we started with daily application of immunomodulator during two weeks (until the beginning of new chemotherapy procedure). Immediately prior to chemotherapy blood samples were taken and lymphocytes transformation and the ratio between helper and suppressor T cells determined. A group of the patients received placebo. After nine months immunomodulator treated patients recovered the intensity of lymphocyte transformation and helper/suppressor ratio was close to the normal values. (Abstract truncated at 2000 characters).
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