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Discovery of novel DNA methylation biomarker panels for the diagnosis and differentiation between common adenocarcinomas and their liver metastases [Elektronski vir]Draškovič, Tina ; Hauptman, NinaDifferentiation between adenocarcinomas is sometimes challenging. The promising avenue for discovering new biomarkers lies in bioinformatics using DNA methylation analysis. Utilizing a 2853-sample ... identification dataset and a 782-sample independent verification dataset, we have identified diagnostic DNA methylation biomarkers that are hypermethylated in cancer and differentiate between breast invasive carcinoma, cholangiocarcinoma, colorectal cancer, hepatocellular carcinoma, lung adenocarcinoma, pancreatic adenocarcinoma and stomach adenocarcinoma. The best panels for cancer type exhibit sensitivity of 77.8-95.9%, a specificity of 92.7-97.5% for tumors, a specificity of 91.5-97.7% for tumors and normal tissues and a diagnostic accuracy of 85.3-96.4%. We have shown that the results can be extended from the primary cancers to their liver metastases, as the best panels diagnose and differentiate between pancreatic adenocarcinoma liver metastases and breast invasive carcinoma liver metastases with a sensitivity and specificity of 83.3-100% and a diagnostic accuracy of 86.8-91.9%. Moreover, the panels could detect hypermethylation of selected regions in the cell-free DNA of patients with liver metastases. At the same time, these were unmethylated in the cell-free DNA of healthy donors, confirming their applicability for liquid biopsies.Vir: Scientific reports [Elektronski vir]. - ISSN 2045-2322 (Vol. 14, iss. 1, [article no.] 3095, Feb. 2024, str. 1-25)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2024Jezik - angleškiCOBISS.SI-ID - 186517251
Povezava(-e):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850119/pdf/41598_2024_Article_53754.pdf
https://link.springer.com/article/10.1038/s41598-024-53754-1?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20240207&utm_content=10.1038/s41598-024-53754-1&fbclid=IwAR3UZFU6bzfLMUidLe2aSgJu631Z6FQ3EXHAzzGFSB_2z1_pxSIngsmMGMk
DOI
Avtor
Draškovič, Tina |
Hauptman, Nina
Teme
adenocarcinoma |
biomarkers, tumor |
diagnosis |
genetics |
cell-free nucleic acids |
DNA methylation |
liver neoplasms |
pathology |
adenokarcinom |
biološki tumorski označevalci |
diagnostika |
genetika |
brezcelične nukleinske kisline |
DNA metilacija |
jetrne novotvorbe |
patologija
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
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Draškovič, Tina | 54662 |
Hauptman, Nina | 27704 |
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