VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
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The influence of cytotoxic drugs on the immunophenotype of blast cells in paediatric B precursor acute lymphoblastic leukaemiaPrelog, Tomaž, medicina ...Flow cytometry plays is important in the diagnosis of acute lymphoblastic leukaemia (ALL) and when antigen-specific immunotherapy is indicated. We have investigated the effects of prednisolone, ... vincristine, daunorubicin, asparaginase and methotrexate on the antigen expression on blast cells that could influence the planning of antigen-specific therapy as well as risk-based treatment assignment. Patients and methods. Patients aged ≤ 17 years with de novo B-cell ALL (B-ALL) were enrolled in the study. Blast cells were isolated and exposed in vitro to 5 individual cytotoxic drugs in logarithmically increasing concentrations. Then, the expression of CD10, CD19, CD20, CD27, CD34, CD45, CD58, CD66c and CD137 antigens was determined by quantitative flow cytometry. Results. Cytotoxic drugs caused dose-dependent or dose-independent modulation of antigen expression. Daunorubicin caused a dose-dependent down-modulation of CD10, CD19, CD34, CD45 and CD58 and an up-modulation of CD137. Vincristine caused a dose-dependent down-modulation of CD19 and CD58 and an up-modulation of CD45. Daunorubicin also caused dose-independent down-modulation of CD27 and prednisolone down-modulation of CD10, CD19, CD27, CD34 and CD58. Down-modulation of CD20 was detected only in relation to the specific dose of daunorubicin. Conclusions. The results of the study have shown that cytotoxic drugs can alter the expression of antigens that are important for immunotherapy. Importantly, daunorubicin, prednisolone and vincristine caused down-modulation of CD19 and CD58, suggesting that these drugs are better avoided during bridging therapy prior to bispecific antibodies or CAR-T cell therapy. In addition, immunophenotypic changes on blast cells induced by different drugs could also influence risk-based treatment assignment.Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 58, no. 1, 2024, str. 133-144)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2024Jezik - angleškiCOBISS.SI-ID - 187712771
Avtor
Prelog, Tomaž, medicina |
Buček, Simon, 1983- |
Brožič, Andreja |
Peterlin, Jakob |
Kavčič, Marko, medicina |
Omerzel, Maša, mag. farm. |
Markelc, Boštjan |
Jesenko, Tanja |
Kloboves-Prevodnik, Veronika
Teme
imunofenotipi |
spremmembe |
kemoterapija |
imunoterapija |
immunophenotypic changes |
chemotherapy |
immunotherapy
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Prelog, Tomaž, medicina | 36767 |
Buček, Simon, 1983- | 39955 |
Brožič, Andreja | 35354 |
Peterlin, Jakob | 51964 |
Kavčič, Marko, medicina | 32049 |
Omerzel, Maša, mag. farm. | 34373 |
Markelc, Boštjan | 32175 |
Jesenko, Tanja | 33227 |
Kloboves-Prevodnik, Veronika | 15076 |
Vir: Osebne bibliografije
in: SICRIS
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