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  • Susceptibility of Borrelia afzelii strains to antimicrobial agents
    Ružić-Sabljić, Eva ...
    The aim of the present study was to determine the susceptibility of Borrelia afzelii strains to antibiotics, and to test the hypothesis that persistence ofborrelia in skin, after therapy, is a ... consequence of resistance to the antibiotic used for treatment. Ten B. afzelii strains isolated from skin of seven adult patients (two with acrodermatitis chronica atrophicans, five with erythema migrans) were studied. In three patients B. afzelii was isolated fromcrythema migrans lesion before antibiotic therapy and 2-3 months after treatment with cefuroxime axetil (two patients) or with ceftriaxone (one patient). MICs and MBCs for amoxicillin, azithromycin, ceftriaxone, cefuroximc, doxycycline and amikacin were measured. There was total resistanceto amikacin but isolates were susceptible to all other antibiotics except one isolate that was resistant to cefuroxime, MIC >4 mgžL. Comparison of MBC values after 3 and 6 wecksć incubation revealed comparible results for azithromycin and ceftriaxone while for amoxicillin, cefuroxime and doxycycline, some differences were found. In one of the patients from whom there were borrelia isolated before and after treatment with cefuroximc axctil, both isolates were resistant to cefuroxime. In the other two patients,the paired isolates were susceptible to the antibiotic used for therapy.
    Vir: International journal of antimicrobial agents. - ISSN 0924-8579 (Letn. 25, 2005, str. 474-478)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 19257817

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