Akademska digitalna zbirka SLovenije - logo
VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • The role of topological features of intercellular communication networks by the synchronization of cellular oscillators [Elektronski vir]
    Markovič, Rene ; Gosak, Marko, 1982- ; Marhl, Marko
    Because of the complexity of processes that govern the regulatory mechanisms which control the cellular functions and dynamic behavior, mathematical models and numerical simulations are needed to ... fully grasp the mechanisms and functions of biological rhythms. In the last decade the theory of complex networks is frequently applied to address those issues. In the present paper we investigate theoretically the role of the intercellular communication network structure by synchronization of cellular oscillators. Motivated by the fact that in biological systems the interplay between the network structure and the dynamics taking place on it is closely interrelated, we develop a spatial network representation of an ensemble of cells in which we can tune the network organization between a scale-free network with dominating long-range connections and a homogeneous network with mostly adjacent neurons connected. Our results reveal that for noise-induced oscillations in excitable cells and for chaotic bursting oscillations the most synchronized response is obtained for the intermediate regime where long- as well as short-range connections constitute the intercellular network. On the other hand, for periodic oscillations it is found than the scale-free network topology ensures the greatest collective response. We argue that those findings are related to flexibility properties of individual cells.
    Vir: "Let's Face Chaos through Nonlinear Dynamics" [Elektronski vir] (Str. 256-267)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 19481864
    DOI

Vnos na polico