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Prediction of clinical response to treatment in Crohn's diseaseGrabec, Igor ; Ferkolj, Ivan ; Grošelj, DušanPrediction of a patient response to treatment with a drug infliximab based on oral clinical parameters is considered. As an optimal predictor the non-parametric regression is applied. Information ... about a specific case is provided by a basis of joint data about clinical parameters and response indicators observed on a test group of patients. The regression utilizes givenclinical parameters of a selected patient to predict his response to a drug administration. In the prediction algorithm a similarity between given parameters and those in the data base is calculated. It is then used as a weight by which the response of a patient from the test group is accounted in the predicted response. The method thus resembles a prediction that is performed by a physician based upon comparison of a treated patient with previously tested ones. The prediction quality is estimated from the discrepancy between predicted and really observed response data. Prediction quality corresponding to particular clinical parameters provides for their ordering and selection of an optimal set of parameters that together yield themaximum quality. The method is demonstrated on the prediction of the clinical response of patients suffering from Crohn's disease to treatment withthe drug infliximab. As given data the dental, periodontal, oral mucosa parameters and the subgingival flora detected by darkfield microscopy are utilized.Vir: CIMED2005 : proceedings (Str. 311-316)Vrsta gradiva - prispevek na konferenciLeto - 2005Jezik - angleškiCOBISS.SI-ID - 19507161
Avtor
Grabec, Igor |
Ferkolj, Ivan |
Grošelj, Dušan
Teme
Crohn Disease |
Drug Therapy |
Predictive Value Of Tests |
Tumor Necrosis Factor |
Antagonists And Inhibitors |
Periodontal Index |
Oral Hygiene Index |
Dental Plaque Index |
Oral Health |
Crohnova bolezen |
Napovedna vrednost testov |
Parodontalni indeks |
Tumor nekrotizirajoči faktor |
Ustna higiena, indeks |
Ustno zdravje |
Zobni plak, indeks
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Grabec, Igor | 00800 |
Ferkolj, Ivan | 10065 |
Grošelj, Dušan | 02125 |
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