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  • Resolution of Budd-Chiari syndrome due to activation of endogenous fibrinolysis that may be induced by weight reduction
    Šabovič, Mišo ; Ključevšek, Tomaž
    We describe a 45-year-old female with polycythemia vera and Leiden factor V mutation, who suffered the subacute form of Budd-Chiari syndrome and was treated with anticoagulants and diuretics. ... Surprisingly, after 3 months clinical signs of Budd-Chiari syndrome resolved; venography disclosed the resolution of thrombosis in the vena cava inferior and hepatic veins. This wasassociated with considerable increase of endogenous fibrinolytic actlvity, documented by a substantial change in the euglobulin clot lysis time, and a decrease of plasminogen activator inhibitor antigen and activity. During the disease the patient followed a diet and significantly reduced her body weight.Putting all data together it could be speculated that weight reduction (along with anticoagulants) considerably activated endogenous fibrinolysis, resulting in spontaneous resolution of Budd-Chiari syndrome. The validity of this explanation should be explored in a larger clinical study.
    Vir: Blood coagulation & fibrinolysis. - ISSN 0957-5235 (Letn. 16, 2005, str. 51-54)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 19772121

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