Akademska digitalna zbirka SLovenije - logo
VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Analysis of ophthalmic inserts Timolol and Nepafenac with different polymers = Proučevanje očesnih vložkov timolola in nepafenaka, izdelanih iz različnih polimerov : University Study Programme Industrial Pharmacy
    Topler, Eva
    Ocular inserts are defined as sterile, thin, drug-impregnated, solid or semisolid devices placed into the cul-de-sac or conjunctival sac, whose size and shape are specially designed for ophthalmic ... application. They contain polymeric support that may or may not contain a drug. The aim of this work was to develop ocular inserts with various characteristics, including different active pharmaceutical ingredients (API) and polymers. The parameters investigated were API solubility, drug loading, polymer type and molecular weight. Those systems were characterized in terms of release, swelling, erosion and disintegration. Twelve different ocular inserts were prepared using two different APIs, timolol hydrogen maleate (TIM) and nepafenac (NEP), as well as four different polymers. TIM insert were additionally prepared at two drug loadings, 5% and 20%. TIM hydrogen maleate is a nonselective beta-adrenergic antagonist, which is given in an eye drop solution to reduce intraocular pressure and is an effective agent for glaucoma and hypertension. The drug is highly water soluble (5 mg/mL), which is the main difference from the second API under investigation NEP, whose water solubility is 0,02 mg/mL. NEP is an ophthalmic non-steroidal anti-inflammatory drug, used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Two hydrophilic polymers HPMC K100LV and HPMC K4M and two lipophilic polymers Kollidon SR and ETHOCEL 10 were used to gain different release profiles. Each ocular insert contained one API in combination with one polymer. Disintegration studies showed faster disintegration for hydrophilic polymers. Comparing HPMC K4M and K100LV, the lower molecular weight polymer showed the shortest disintegration time. This was in accordance with release studies, where the lower molecular weight polymer showed the fastest release. Also swelling and erosion were higher for hydrophilic polymers. Higher swelling was seen in HPMC K4M than in HPMC K100 LV. Release studies showed a faster release for 20% drug loading when using a hydrophilic polymer. 5% TIM showed quicker release than 5% NEP, which was expected based on the lower water solubility of NEP.
    Vrsta gradiva - magistrsko delo ; neleposlovje za odrasle
    Založništvo in izdelava - Ljubljana : [E. Topler], 2024
    Jezik - angleški
    COBISS.SI-ID - 198584835

Knjižnica/institucija Kraj Akronim Za izposojo Druga zaloga
Fakulteta za farmacijo, Ljubljana Ljubljana FFALJ v čitalnico 1 izv.
loading ...
loading ...
loading ...

Vnos na polico