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  • Diagnostična vloga prokalcitonina : magistrsko delo
    Jereb, Matjaž, 1961-
    Meningitis is a common disease in our place. Particularly in case of bacterialcentral nervous system infection it continues to cause significant mortality, despite the advances in antibiotic and ... intensive care therapy. Rapid diagnosis and therapy have crucial influence on clinical outcomes. Patients with viral meningitis have not so rarely clinical and laboratory parameters of bacterial infection which usually lead to unnecessary antibiotictherapy. Delay of antimicrobial treatment could be on the other sidefatal in case of noncharacteristic bacterial meningitis. During the last few years several studies have been reported on the new inflammation peptid procalcitonin (PCT), which concentration increases in the setting of bacterialinfection. In the present study we wanted to find out whether there is any difference in plasma PCT level between patients with bacterial meningitis and patients with viral infection of central nervous system, and ifmeasurement of PCT level in cerebrospinal fluid might have additional diagnostic value. Seventeen patients with purulent and 28 patients with aseptic meningitis were included in the prospective clinical study. The mean plasma PCT level in patients with purulent meningitis was 11.50 ngžml and meanplasma PCT level in patients with aseptic meningitis was 0.28 ngžml (p<0.001). Two patients in purulent meningitis group had plasma PCT level under a cutoff value of 0.5 ngžml. In both cases Listeria monocytogenes has been isolated from cerebrospinal fluid. No one in aseptic meningitis group hadeleveted PCT level. Eight patients with purulent meningitis had elevated PCT level in cerebrospinal fluid and in all cases PCT in plasma was high. The measurement of PCT in plasma and cerebrospinal fluid might be of value in the differential diagnosis of meningitis due to either bacteria or viruses. PCT value higher then 0.5 ngžml appears to be a reliable indicator of bacterial central nervous system infection.
    Vrsta gradiva - magistrsko delo
    Založništvo in izdelava - Ljubljana : [M.Jereb], 1999
    Jezik - slovenski
    COBISS.SI-ID - 2062356

Knjižnica/institucija Kraj Akronim Za izposojo Druga zaloga
MF, Centralna medicinska knjižnica, Ljubljana Ljubljana CMK na dom 1 izv.
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