Akademska digitalna zbirka SLovenije - logo
VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Fetomaternal alloimmune thrombocytopenia - diagnostics, therapy and prophylaxis
    Rožman, Primož, 1954- ; Telebak, Tanja
    Fetomaternal alloimmune thrombocytopenia (FMAIT) is a disease of the fetus andneonate caused by anti-HPA antibodies produced by pregnant women in the course of an immune response to fetal HPA ... alloantigens inherited from the father. In whites, it is usually caused by the anti-HPA-1a (in 80-90% of cases), less frequently by anti-HPA-5b (in 5-15% cases) and only rarely by other antibodies. The incidence of FMAIT is around 1.5 in 1000 births and it is responsible for around 10% of all neonatal thrombocytopenias with a platelet count below 100x109/L. The fetus or neonate with FMAIT displays mucosal and skin bleeding, whereas in severe cases, intracranial haemorrhages are observed with consequent neurological damage or death. The best treatment of severe FMAIT is a transfusion of HPA-compatible platelets to the affected fetus or newborn. The use of i.v. immunoglobulins for pregnant women is less effective. If the fetus shows a serious tendency of bleeding due to thrombocytopenia, regular weekly cordocenteses with intrauterine platelet transfusions are indicated. This treatment still bears an approximate 2% mortality rate. Since the prevention of FMAIT could be easier than its therapyand since the incidence of HPA-1a alloimmunizations in whites justifiesthe introduction of preventive screening tests, the question of a prenatal programme for the detection of pregnancies at risk of FMAIT was raised, which would bi similar to the routine prenatal programme for prevention of haemolitic disease of the newborn due to RhD incompatibility.
    Vir: "Novine u prenatalnoj i perinatalnoj zastiti 2005 - Aloimune citopenije - profilaksa, dijagnostika i terapija" (Str. 31-38)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 21030105

Vnos na polico