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  • Prognostic value of the QTc interval after cardiac transplantation
    Vrtovec, Bojan, 1972- ...
    Background: Although QTc interval prolongation is considered a risk factor foradverse outcome in the non-transplant population, its predictive value in heart transplant recipients has not been ... studied yet. This study was conductedto determine whether prolonged QTc interval is a useful predictor of outcome in heart transplant recipients. Methods: QTc intervals were measured in 587 adult patients who underwent heart transplantation between May 1982 andJanuary 2002. QT interval duration was determined by averaging 3 consecutive beats in all 12 leads of the standard electrocardiogram (ECG) and corrected with the Bazett formula. Baseline ECGs were obtained within 7 days after transplantation; follow-up ECGs were recorded annually at the time of routine angiography. Patients were followed over 85 65 months (range, 3 months-17 years). Results: During follow-up, 241 patients died. The mean QTc interval duration in these patients was comparable with that in the remaining cohort (432 26 msec vs 423 25 msec, p = 0.07). However, patients with a relative increase in QTc duration of >- 10% between the first and second post-transplantation year (deltaQTc >- 10%) had a 6.86-times higher risk of dying compared with patients with deltaQTc < 10% (p = 0.0005). Furthermore, deltaQTc >- 10% was the only independent predictor of long-term rnortality on multivariate analysis (p = 0.0008). Conclusions: A relative increase in QTc interval duration of >- 10% between the first and second posttransplantation year is a strong, independent predictor of mortality in heart transplant recipients.
    Vir: Journal of heart and lung transplantation. - ISSN 1053-2498 (Letn. 25, št. 1, 2006, str. 29-35)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - angleški
    COBISS.SI-ID - 21059545

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