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Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytesSu, Chun-Li ...Lipolysis in adipocytes governs the release of fatty acids for the supply of energy to various tissues of the body. This reaction is mediated by hormone-sensitive lipase (HSL), a cytosolic enzyme, ... and perilipin, which coatsthe lipid droplet surface in adipocytes. Both HSL and perilipin are substrates for polyphosphorylation by protein kinase A (PKA), and phosphorylation of perilipin is required to induce HSL to translocate from thecytosol to the surface of the lipid droplet, a critical step in the lipolytic reaction (Sztalryd C., Xu, G., Dorward, H., Tansey, J. T., Contreras, J.A, Kimmel, A. R., and Londos, C. (2003) J. Cell Biol. 161, 1093-1103). In the present paper we demonstrate that phosphorylation at one ofthe two more recently discovered PKA sites within HSL, serines 659 and 660, is also required to effect the translocation reaction. Translocation does not occur when these serines residues are mutated simultaneously to alanines. Also, mutation of the catalytic Ser-423 eliminates HSL translocation, showing that the inactive enzyme does not migrate to the lipid droplet upon PKA activation. Thus, HSL translocation requires the phosphorylation of both HSL and perilipin.Vir: The Journal of biological chemistry. - ISSN 0021-9258 (Letn. 278, št. 44, 2003, str. 43615-43619)Vrsta gradiva - članek, sestavni delLeto - 2003Jezik - angleškiCOBISS.SI-ID - 21683417
Avtor
Su, Chun-Li |
Sztalryd, Carole |
Contreras, Juan Antonio |
Holm, Cecilia |
Kimmel, Alan R. |
Londos, Constantine.
Teme
Adipocytes |
Metabolism |
Animals |
Blotting, Northern |
Catalysis |
Cell Differentiation |
Cholesterol Esterase |
Metabolism |
Cyclic Amp-Dependent Protein Kinases |
Metabolism |
Cytosol |
Enzymology |
Dna Mutational Analysis |
Immunoblotting |
Mice |
Microscopy, Fluorescence |
Mutation |
Phosphoproteins |
Metabolism |
Phosphorylation |
Serine |
Chemistry |
Adipociti |
Blot, Northern |
Celična diferenciacija |
Ciklične AMP-odvisne, beljakovinske kinaze |
Citosol |
DNA mutacijska analiza |
Fosfoproteini |
Fosforilacija |
Holesterolna esteraza |
Imunoblot |
Kataliza |
Mikroskopija fluorescenčna |
Miši |
Mutacija |
Serin |
Živali
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Su, Chun-Li | ![]() |
Sztalryd, Carole | ![]() |
Contreras, Juan Antonio | 28452 |
Holm, Cecilia | ![]() |
Kimmel, Alan R. | ![]() |
Londos, Constantine. | ![]() |
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