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  • Elektrookulografija in slikovna elektroretinografija v diagnostiki Bestove makularne distrofije : magistrsko delo
    Jarc-Vidmar, Martina
    Background: Electrooculography (EOG) is important noninvasive electrodiagnostic test for evaluating the function of the retinal pigment epithelium and retinal photoreceptors. Till now none among the ... existing electrophysiologic methods in Slovenia could detect the function of the retinal pigment epithelium. In 1993 the Intemational Society for Clinical Electrophysiology of Vision (ISCEV) accepted standards for recording and confirming normal values for electrooculograms under defined conditions to improve the comparability of the electrooculographic data throughout the world. EOG is one of the crucial diagnostic tests for Best's dystrophy, which is second most common hereditary macular dystrophy. The etiology of the disease is not yet completely understood, the genetic linkage analysis mapped the disease causing gene to chromosome 11. The histopathologic and electrophysiologic studies disagree whether the primary site of the lesion is the retinal pigment epithelium or the neurosensory retina. AimsČ The aim of the study was to develop electrooculography in accordance with ISCEV standardsand to test its accuracy in the diagnosis of Bestćs disease, where the EOG results should be invariably abnormal in all affected members. For detecting early abnormality of neurosensory retina in patients with Best's disease pattem electroretinography (PERG) was used, which was compared to visual acuity. Patients and methodsČ The EOG was recorded on 30 healthy individuals, whose age ranged from 22 to 39 years. The optimum type of analysis was chosen and the normal values were determined. Then EOG was recorded on 25 patients from 6 families with presumed Bestćs disease, whose age ranged from 9 to 73 years. The anamnesis was taken from all the patients. They were clinically examined and visual acuity was determined. Patients: fundi were photographed and fluorescein angiography was done on adult patients. (Abstract truncated at 2000 characters).
    Vrsta gradiva - magistrsko delo
    Založništvo in izdelava - Ljubljana : [M. Jarc-Vidmar], 2000
    Jezik - slovenski
    COBISS.SI-ID - 2175252

Knjižnica/institucija Kraj Akronim Za izposojo Druga zaloga
MF, Centralna medicinska knjižnica, Ljubljana Ljubljana CMK na dom 1 izv.
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