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  • Vpliv statinov in fibratov na funkcionalne in morfološke lastnosti arterijske stene pri bolnikih s kombinirano hiperlipidemijo : [magistrso delo]
    Šebeštjen, Miran
    Background: Endothelial dysfunction manifested by diminished flow-mediated dilation (FMD) of brachial artery has been shown to improve after treatment with several lipolytics in patients with ... hypercholesterolemia. However, there is no data of the effects of cerivastatin, new HMG-CoA reductase inhibitor andfibric acid derivate fenofibrate on the endothelial dysfunction in subjectswith combined hyperlipidemia. Subjects and methodsČ Forty middle-aged males with combined hyperlipidemia with no other atherogenic risk factors wererandomised, after 6 week run-in phase with AHA step I diet treatment, to 12 week treatment either with fenofibrate (250 mg daily) or cerivastatin. Cerivastatin was given in daily dose of 0,2 mg for 6 weeks and was increased to 0,4 mg daily in 10 patients, who did not achieve LDL-cholesterol goal of <3,0 mmol/I. At the beginning and every 6 weeks physical examination and anthropometric measurement were performed and blood total, LDL and HDL cholesterol, glucose, insulin, apolipoprotein A1, apolipoprotein B, lipoprotein (a), tissue type plasminogen activator (t-PA) antigen and activity, plasminogen activator inhibitor (PAI-1) antigen and activity, fibrinogen and euglobulin clot lysis time were detennined. We estimated the presence of small, dense LDL particles with relation LDL cholesterol/apolipoprotein B. Insulin resistance was calculated by using HOMA mathematical model. The endothelium-dependent and endothelium-independent dilation were calculated using the diameters of the brachial artery measured by high resolution ultrasound at rest, after reactive hyperemia and after sublingual glyceriltrinitrate. (Abstracts truncated at 2000 characters.)
    Vrsta gradiva - magistrsko delo
    Založništvo in izdelava - Ljubljana : [M. Šebeštjen], 2000
    Jezik - slovenski
    COBISS.SI-ID - 2182420

Knjižnica/institucija Kraj Akronim Za izposojo Druga zaloga
MF, Centralna medicinska knjižnica, Ljubljana Ljubljana CMK na dom 1 izv.
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