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  • The role of gender and sex hormones in ischemic-reperfusion injury in isolated rat hearts : ischemic-reperfusion injury in isolated male rat hearts is reduced only after pretreatment of animals but not with direct administration of testosterone to the isolated heart
    Kuhar, Primož ; Lunder, Mojca, dr. med., 1980- ; Drevenšek, Gorazd
    To establish potential anti-ischemic effects of testosterone and estradiol on myocardium we used isolated rat hearts in accordance with Langendorff, exposedto 40 min of ischemia and reperfusion. Rats ... were pretreated for 10 days, males with testosterone and females with estradiol and injuries from those hearts were compared to the hearts where both drugs were applied to the isolated hearts directly. The myocardial injuries were determined by changes in coronary flow, incidence of arrhythmias and lactate dehydrogenase release rates used as markers for level of cardiac injury during reperfusion. Coronaryflow in the hearts of animals pretreated with estradiol during reperfusion increased by 68.7+-3.6 % (P < 0.001) and in those pretreated with testosterone by 50.1+-2.1 % (P < 0.05) vs. control hearts. Lactate ehydrogenase release rates decreased in the hearts of animals pre-treated withestradiol by 55.7+-1.9 % (P < 0.01) vs. controls and by 58.8+-3.0 (P < 0.01) vs. directly applied estradiol. The incidence of ventricular fibrillation decreased after 10 days application of drugs, from 9.42+-0.81 minto 4.58+-0.93 min (P < 0.05) with estradiol and from 9.19+-1.05 min to 4.65+-0.51 min (P < 0.05) with testosterone. The duration of heart arrest decreased in 10 days application of testosterone from 2.42+-0.16 min to 20.0+-12.26 s (P<0.01). Hearts from animals pretreated for 10 days with estradiol showed more cardioprotective effects during reperfusion than those pretreated with testosterone. Testosterone pretreatment, espite being less effective in cardioprotection than estradiol, improved coronary flow and decreased arrhythmias as effectively as estradiol.
    Vir: European Journal of Pharmacology. - ISSN 0014-2999 (Letn. 561, 2007, str. 151-159)
    Vrsta gradiva - članek, sestavni del
    Leto - 2007
    Jezik - angleški
    COBISS.SI-ID - 22124761

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