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Loss of heterozygosity of APC and CDH1 genes in laryngeal squamous cell carcinomaPećina-Šlaus, Nives ; Kljaić-Dujić, Milka ; Nikuševa-Martić, TamaraThe molecular mechanisms involved in the development and progression of laryngeal cancer, specifically squamous cell carcinoma, still need further investigation and elucidation. Twenty-two laryngeal ... squamous cell carcinomas were analyzed in our study regarding genetic changes of two tumor suppressor genes: Adenomatous polyposis coli (APC) and E-cadherin (CDH1). APC gene instability was tested by polymerase chain reaction (PCR)/loss of heterozygosity (LOH) using the restriction fragment length polymorphism (RFLP) method. The samples were also screened for mutations using the heteroduplex method. E-cadherin gene was analyzed by PCR amplification of tetranucleotide marker (D16S752) linked to E-cadherin gene. The results of our analysis showed three samples with LOH of the APC gene out of 15 heterozygous patients (20%). Only one LOH of the CDH1 gene (5.5%) out of 18 heterozygous patients was discovered. D16S752 marker did not reveal any replication error-positive samples. There were six samples showing heteroduplexes (33%) encompassed in APC's exon 11. Altogether, nine samples (41%) showed alterations of the APC gene. Our results suggest that alterations of APC gene may have a role in squamous cell carcinoma development. Detected LOH of the E-cadherin gene indicates that genetic change sof this gene are not very frequent, but that other components of the wnt signaling cascade may also be involved.Vir: Pathology research and practice. - ISSN 0344-0338 (Vol. 201, no. 8-9, 2005, str. 557-563)Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasleLeto - 2005Jezik - angleškiCOBISS.SI-ID - 2216255
Avtor
Pećina-Šlaus, Nives |
Kljaić-Dujić, Milka |
Nikuševa-Martić, Tamara
Teme
Carcinoma, squamous cell |
Genetics |
Pathology |
Karcinom, ploščatocelični |
Genetika |
Patologija |
DNA, neoplasm |
Analysis |
DNA, novotvorba |
Analiza |
Genes, APC |
Geni, APC |
Genetic markers |
Genetski označevalci |
Laryngeal neoplasms |
Genetics |
Pathology |
Grlo, novotvorbe |
Loss of heterozygosity |
Genetics |
Izguba heterozigotnosti |
Genetika |
Microsatellite repeats |
Mikrosatelitne ponovitve |
Polymerase chain reaction |
Polimerazna verižna reakcija |
Polymorphism, restriction fragment length |
Polimorfizem, omejene dolžine fragmentov |
Cadherins |
Genetics |
Kadherini |
Genetika
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Pećina-Šlaus, Nives | ![]() |
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