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  • Mehanizem transporta glukoze v osmotskem šoku v inzulindko rezistentnih 3T3-L1 adipocitih = Mechanism of osmotic shock-induced glucose transport in insulin resistant 3T3-L1 adipocytes : doctoral dissertation
    Janež, Andrej, 1971-
    Osmotic shock treatment of 3T3-L1 adipocytes causes an increase in glucose transport activity and translocation of GLUT-4 protein similar to that elicited by insulin treatment. Insulin stimulation of ... GLUT-4 translocation andglucose transport activity was completely inhibited by wortmannin, however,activation by osmotic shock was only partialy blocked. Additionally, we have found that the newly identified insulin rcceptor substrate (IRS) Gab-1(Grb2-associated binder-1) is tyrosine phosphorylated following sorbitol stimulation. Treatment of cells with the tyrosine kinase inhibitor genestin inhibited osmotic shockstimulated Gab-1 phosphorylation, as well as shock-induced glucose transport. rurthennore, pretreatment with the selective Src family kinase inhibitor PP2 completely inhibited the ability of sorbitol treatment to cause tyrosine phosphorylation of Gab-1. We have also shown that microinjection of anti-Gab-1 antibody inhibits osmotic shock-induced GLUT-4 translocation. Furthermore, phosphorylated Gab-1 binds and activates phosphatidylinositol 3-kinase (PI 3-kinase) in response to osmotic shock. The PI 3-kinase activity associated with Gab-1 was 82% of that associated with antiphosphotyrosine, indicating that Gab-I is the major site for PI 3-kinase recruitment following osmotic shock stimulation. (Abstract truncated at 2000 characters)
    Vrsta gradiva - disertacija
    Založništvo in izdelava - Ljubljana : [A. Janež], 2000
    Jezik - angleški, slovenski
    COBISS.SI-ID - 2227220

Knjižnica/institucija Kraj Akronim Za izposojo Druga zaloga
MF, Centralna medicinska knjižnica, Ljubljana Ljubljana CMK na dom 2 izv.
Narodna in univerzitetna knjižnica, Ljubljana Ljubljana NUK v čitalnico 1 izv.
Univerzitetna knjižnica Maribor Maribor UKM v čitalnico 1 izv.
ni za izposojo 1 izv.
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