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  • Upregulation of synaptotagmin IV protein in kainate-induced seizures
    Glišović, Špela, nevrobiologija, 1979- ...
    Synaptotagmin IV is a product of immediate early-responsegene.lt is involved in the regulated neurosecretion in the brain. Its putative role, however, in vesicular transport and localization in ... secretory vesicles is still a matterofdebate. Here we followed the spatiotemporal pattern of synaptotagmin IV protein upregulation in the hippocampus, caudate putamen, nucleus accumbens, nucleus amygdalae, piriform and entorhinal cortices of rats with kainate-induced seizures. We found that upregulation pattern par alleled the direction of depolarization through the hippocampus and also reflecting seizure activity spreading to other brain regions. We speculate that synaptotagmin IV may have a role in the vesicular transport of the upregulatedpeptides and proteins involved in the plasticity and/or neurodegeneration provoked by the kainate.
    Vir: Neuroreport. - ISSN 0959-4965 (Letn. 18, št. 8, 2007, str. 831-835)
    Vrsta gradiva - članek, sestavni del
    Leto - 2007
    Jezik - angleški
    COBISS.SI-ID - 22334681

vir: Neuroreport. - ISSN 0959-4965 (Letn. 18, št. 8, 2007, str. 831-835)
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