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Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantationZver, Samo, 1966- ...High-dose cyclophosphamide is a well-known mobilization regimen in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Highly differing rates of cardiac ... complications associated with high-dose cyclophosphamide have been reported. To date, no systematic clinical study has investigated high-dose cyclophosphamide mobilization regimens in multiple myeloma patients and evaluated its cardiotoxicity. We administered high-dose cyclophosphamide (4 g/m2) to 23 consecutive multiple myeloma patients and followed the patients for 15 days by serially measuring the cardiotoxicity biomarkers troponin I (TnI), brain natriuretic peptide (BNP), and endothelin 1 (ET-1). Systolic and diastolic left ventricular function was assessed by complete echocardiography before and at 6 to 8 weeks after the therapy. Patients younger than 55 years showed significant differences between basal TnI levels and TnI concentrations determined at 15 days after high-dose cyclophosphamide treatment (P = .028). Significant differences between basal BNP concentrations and BNP levels measured at 8 hours after high-dose cyclophosphamide treatment were found in the entire group of patients as well as in 2 subgroups, patients younger than 55 years and those older than 55 years (P <.0001, P <.001, and P = .001, respectively).ET-1 results for the entire group of patients showed a significant difference between baseline ET-1 values and ET-1 values determined8 hours after high-dose cyclophosphamide administration (P = .004). Echocardiographic measurements revealed a barely nonsignificant decrease in cardiac output after high-dose cyclophosphamide infusion compared with pretreatment values (P = .06), a result in accord with echocardiographically detected increases in mild functional mitral regurgitation (P = .025). (Abstract truncated at 2000 characters)Vir: International journal of hematology. - ISSN 0925-5710 (Vol. 85, no. 5, 2007, str. 408-414)Vrsta gradiva - članek, sestavni delLeto - 2007Jezik - angleškiCOBISS.SI-ID - 23002841
Avtor
Zver, Samo, 1966- |
Zadnik, Vesna, 1975- |
Bunc, Matjaž |
Rogel, Polona, 1976 |
Černelč, Peter |
Koželj, Mirta
Teme
Plasmacytoma |
Drug Therapy |
Cyclophosphamide |
Toxicity |
Hematopoietic Stem Cell Transplantation |
Troponin I |
Natriuretic Hormone |
Echocardiography |
Endothelin-1 |
Ventricular Dysfunction, Left |
Electrocardiography |
Stroke Volume |
Ciklofosfamid |
Hematopoetska matična celica, presaditev |
Natriuretični hormon |
Plazmacitom |
Troponin I |
Ehokardiografija |
Elektrokardiografija |
Endotelin-1 |
Srce, prekat levi, disfunkcija |
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Zver, Samo, 1966- | 23817 |
Zadnik, Vesna, 1975- | 23050 |
Bunc, Matjaž | 15667 |
Rogel, Polona, 1976 | 24602 |
Černelč, Peter | 07012 |
Koželj, Mirta | 04573 |
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