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  • Metabolic and cardiovascular changes in women with polycystic ovary syndrome
    Meden-Vrtovec, Helena ; Vrtovec, Bojan, 1972- ; Osredkar, Joško, 1955-
    Objective: To analyze the relationship between QTc interval and cardiovascularrisk factors in women with polycystic ovary syndrome (PCOS). Methods: Study group included 119 PCOS women (age: ... 32.2+/-5.2 years) and the control group 64 age-matched healthy women; they all underwent QT interval measurement, and plasma levels of high-sensitivity CRP (hsCRP), endothelin-1 (ET1), insulin, and testosterone determinations. Results: In PCOS women hsCRP (2.35+/-2.14 mg/L vs. 1.01+/-1.28 mg/L; P=0.04), ET1 (23.6+/-10.3 ng/L vs. 7.7+/-15.9 ng/L; P=0.01), and insulin (16.5+/-7.8 mIU/L vs. 11.8+/-10.7 mIU/L;P=0.03) levels were significantly higher, and QTc interval significantlyshorter than in controls (401+/-61 ms vs. 467+/-61 ms; P=0.007). In 67 (56%) PCOS patients with a short QTc interval (<400 ms), plasma testosterone levels were significantly higher than in PCOS women with normal QTc interval (2.3+/-2.1 nmol/L vs. 1.4+/-1.7 nmol/L; P=0.02). Conclusion: In patients with polycystic ovary syndrome increased testosterone levels may attenuate the effects of coronary risk factors.
    Vir: International journal of gynaecology & obstetrics. - ISSN 0020-7292 (Letn. 99, št. 2, 2007, str. 87-90)
    Vrsta gradiva - članek, sestavni del
    Leto - 2007
    Jezik - angleški
    COBISS.SI-ID - 23367385

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