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Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanationTuohimaa, Pentti ...Background: Skin cancers are known to be associated with sun exposure, whereassunlight through the production of vitamin D may protect against some cancers. The aim of this study was to assess ... whether patients with skin cancerhave an altered risk of developing other cancers. Methods: The study cohort consisted of 416,134 cases of skin cancer and 3,776,501 cases of non-skin cancer as a first cancer extracted from 13 cancer registries. 10,886 melanoma and 35,620 non-melanoma skin cancer cases had second cancers. The observed numbers (O) of 46 types of second primary cancer after skin melanoma,basal cell carcinoma or non-basal cell carcinoma, and of skin cancersfollowing non-skin cancers were compared to the expected numbers (E) derived from the age, sex and calendar period specific cancer incidence rates in each of the cancer registries (O/E=SIR, standardised incidence ratios). Rates from cancer registries classified to sunny countries (Australia, Singapore and Spain) and less sunny countries (Canada, Denmark, Finland, Iceland, Norway, Scotland, Slovenia and Sweden) were compared to each other. Results: SIR of all second solid primary cancers (except skin and lip) after skin melanoma were significantly lower for the sunny countries (SIR(S)=1.03; 95% CI 0.99-1.08) than in the less sunny countries (SIR(L)=1.14; 95%CI 1.11-1.17). The difference was more obvious after non-melanoma skin cancers: after basal cell carcinoma SIR(S)/SIR(L)=0.65 (95%CI=0.58-0.72); after non-basal cell carcinoma SIR(S)/SIR(L)=0.58 (95%CI=0.50-0.67). In sunny countries, the risk of second primary cancer after non-melanoma skin cancers was lower for most of the cancers except for lip, mouth and non-Hodgkin lymphoma. Conclusions: Vitamin D production in the skin seems to decrease the risk of several solid cancers (especially stomach, colorectal, liver and gallbladder, pancreas, lung, female breast, prostate, bladder and kidney cancers). (Abs. trunc. at 2000 ch.)Vir: European Journal of Cancer. - ISSN 0959-8049 (Letn. 43, št. 11, 2007, str. 1701-1712)Vrsta gradiva - članek, sestavni delLeto - 2007Jezik - angleškiCOBISS.SI-ID - 23474905
Avtor
Tuohimaa, Pentti |
Pompe-Kirn, Vera
Teme
Adult |
Aged |
Carcinoma, Basal Cell |
Epidemiology |
Incidence |
Melanoma |
Epidemiology |
Neoplasms, Radiation-Induced |
Epidemiology |
Neoplasms, Second Primary |
Epidemiology |
Registries |
Risk Assessment |
Risk Factors |
Skin Neoplasms |
Epidemiology |
Sunlight |
Adverse Effects |
Vitamin D |
Pharmacology |
Dejavniki tveganja |
Incidenca |
Karcinom bazalnocelični |
Kožne novotvorbe |
Melanom |
Novotvorbe povzročene z obsevanjem |
Novotvorbe, druge primarne |
Odrasli |
Registri |
Sončna svetloba |
Starostniki |
Tveganje, ocenjevanje |
Vitamin D
Vnos na polico
Trajna povezava
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Faktor vpliva
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Tuohimaa, Pentti | |
Pompe-Kirn, Vera | 03279 |
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