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  • Določanje in spremljanje molekularnoepidemioloških lastnosti izbruhov povzročenih s kalicivirusi v Sloveniji v letih 2000 do 2006 = Detection and molecular epidemiology of calicivirus outbreaks in Slovene from 2000 to 2006
    Zimšek Mijovski, Janet ...
    Human caliciviruses from the Caliciviridae family are the main cause of acute non-bacterial gastroenteritis in humans of all ages. They appear in both, epidemic and sporadic cases. Caliciviruses can ... not be propagated in cell cultures. Therefore, molecular methods for caliciviral detection, which represent the basis of molecular epidexniology, have been recently introduced.For studying molecular epidemiology of caliciviral outbreaks, were collected during the period from 2000 to 2006. Within a sample collection of 120 outbreaks, the caliciviral RNA regions coding for viral polymerase were analysed. In 2000, the first outbreaks caused by noroviruses from Caliciviridae family were detected. Almost one half of all outbreaks occured during the winter season, confirming wintertime seasonality of the desease. The highest frequency of outbreaks was observed in populations prone to caliciviral infection, i. e. those residing in semi-closed or closed environments, such as residential homes, day care centres, schools and hospitals. Few outbreaks were alimentary, i. e. caused by contaminated food inhotels and restaurants, or hydric, i. e. caused by contaminated drinking water. In the years 2002, 2005 and 2006, a significant rise in the number of outbreaks was noticed, probably due to emergence of a new viral strain with increased pathogenicity. The most frequently detected strain was GGIL4 genotype of the noroviral genogroup GGII. Genotypes from the GGI genogroup were detected rarely, although they caused a higher number of outbreaks in theyears, with a lower total number of outbreaks. This confirms a hypothesis that the number of outbreaks depends on the predominance of a more virulent strain of noroviruses.
    Vir: Črevesne okužbe : zbornik predavanj, Ljubljana 23-24 november 2007 (Suppl. 2, 2007, str. 75-81)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2007
    Jezik - slovenski
    COBISS.SI-ID - 23590873

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