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  • Funkcijske in morfološke značilnosti perifernih arterij pri bolnikih z Buergerjevo boleznijo : magistrsko delo
    Joras, Majda
    Buerger's disease (BD) is a segmental occlusive vascular disease, which primarily affects small distal arteries, mostly in young male adults. The disease is closely related to cigarette smoke ... exposure and it goes on with exacerbations, while other risk factors for atherosclerosis are usually absentat the time of setting the diagnosis. It is not quite clear yet, whetherthe disease alterations of vessel wall are consequences of inflammation. The aim of the present study was to find out if there are any functional disorders and asymptomatic morphological changes at the time of thedisease remission on peripheral arteries, where the disease did not expressclinically. At the same time we assessed the presence of laboratory signs of inflammation and endothelial damage. We wanted to test the hypothesis, that BD is principally systemic inflammatory process, which is also present at the time of the disease remission and accompanied by diminished functional capability of the peipheral arteries. Subjects and methods. 14 patients with BD (10 male, 4 female) and the same number of age and sex matched healthy volunteers were included in our study. By measuring haemodynamic changes in brachial artery during the provocation tests (reactivehyperaemia, sublingual administration of nitroglycerin) we echographically assessed the capability of endothelium- dependent and endotheliumindependent dilation of brachial artery. We also echographically investigated the structure of the wall of carotid arteries and measured intima-media thickness (IMT). Besides basic haematological and biochemical examinations we determined blood fibrinolytic activity and blood concentrationof some cell adhesion molecules (ICAM-l, VCAM-l, E-selectin) and TNF-alpha. (Abstract truncated at 2000 characters).
    Vrsta gradiva - magistrsko delo
    Založništvo in izdelava - Ljubljana : [M. Joras], 2002
    Jezik - slovenski
    COBISS.SI-ID - 2383892

Knjižnica/institucija Kraj Akronim Za izposojo Druga zaloga
MF, Centralna medicinska knjižnica, Ljubljana Ljubljana CMK na dom 1 izv.
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