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  • Prediction of clinical response to anti-TNF treatment by oral parameters in Crohn's disease
    Grošelj, Dušan ...
    Background/Aims: The aim of our work was to predict the clinical response of Crohn's disease (CD) patients to anti-tumor necrosis factor (TNF) treatment bydental, periodontal, and oral mucosa ... parameters. Methodology: In 5 patients with luminal CD and in 9 patients with fistulizing CD, oral symptoms and signsbefore drug administration were assessed by 27 parameters, including: a) Decayed-, missing-, filled -, healthy -, nonvital -, root canal filled -, total number of - and impacted teeth; b) Oral ulcers, swelling of lips and cheeks, recurrent oral aphthae and hyperplasia of the mucosa; c) Width of keratinized gingiva, probing depth, gingival margin, clinical attachment level, bleeding on probing, plaque index, gingival index and gingival crevicular fluid (GCF) volume; d) The percentage of 8 morphotypes of subgingival plaque detected by darkfield microscopy (DFM), with the total number of bacteria examined. A new statistical prediction method has been introduced. Results: At time lapse of 8 weeks after infliximab administration the prediction quality estimated from 8 optimal parameters attained a value of0.63. However, with time lapse increasing to 3 months, the prediction quality decreased to 0.21, indicating that oral and response parameters becamemore statistically independent. Conclusions: This indicates that the oral state parameters could provide a sound basis for predicting the response of patients to infliximab administration.
    Vir: Hepato-gastroenterology. - ISSN 0172-6390 (Letn. 55, št. 81, 2008, str. 112-119)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 24149977

vir: Hepato-gastroenterology. - ISSN 0172-6390 (Letn. 55, št. 81, 2008, str. 112-119)
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