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The thymus is a source of B-cell-survival factors-APRIL and BAFF-in myasthenia gravisThanggarajh, Mathula ...The accumulation of B cells in the thymus is a common feature of myasthenia gravis (MG). To understand whether factors enhancing B-cell survival are increased in MG, we studied the expression of ... APRIL, BAFF and three of their receptors in the thymus. In hyperplastic thymi, macrophages expressed APRIL and BAFF, and germinal-center B cells, BAFF-R. CD138-positive plasma cells were abundant in MG thymi. By contrast, BCMA-positive plasma cells were scarce. The expression of APRIL and BAFF in MG thymi may reflect the establishment of an environment favorable to B-cell survival.Vir: Journal of neuroimmunology. - ISSN 0165-5728 (Letn. 178, št. 1/2, 2006, str. 161-166)Vrsta gradiva - članek, sestavni delLeto - 2006Jezik - angleškiCOBISS.SI-ID - 24548825
Avtor
Thanggarajh, Mathula |
Masterman, Thomas |
Helgeland, Lars |
Rot, Uroš, 1967- |
Jonsson, Malin V. |
Egil Eide, Geir |
Pirskanen, Ritva |
Hillert, Jan |
Jonsson, Roland
Teme
Adult |
Aged |
Aged, 80 And Over |
B-Lymphocytes |
Immunology |
Enzyme-Linked Immunosorbent Assay |
Immunohistochemistry |
Membrane Glycoproteins |
Analysis |
Biosynthesis |
Immunology |
Membrane Proteins |
Analysis |
Biosynthesis |
Immunology |
Myasthenia Gravis |
Immunology |
Proteoglycans |
Analysis |
Biosynthesis |
Immunology |
Receptors, Tumor Necrosis Factor |
Analysis |
Biosynthesis |
Immunology |
Thymus Gland |
Cytology |
Immunology |
Metabolism |
Priželjc |
Starostniki |
Starost 80 in več |
Imunohistokemija |
Membranski glikoproteini |
Odrasli |
Membranske beljakovine |
Encimsko-vezani imunosorbentni test |
Miastenija gravis |
Receptorji, tumorje nekrotizirajoči faktor |
Limfociti B |
Proteoglikani
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Thanggarajh, Mathula | ![]() |
Masterman, Thomas | ![]() |
Helgeland, Lars | ![]() |
Rot, Uroš, 1967- | 15441 |
Jonsson, Malin V. | ![]() |
Egil Eide, Geir | ![]() |
Pirskanen, Ritva | ![]() |
Hillert, Jan | ![]() |
Jonsson, Roland | ![]() |
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