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Complex evolution of the DAL5 transporter familyHellborg, Linda ...Background: Genes continuously duplicate and the duplicated copies remain in the genome or get deleted. The DAL5 subfamily of transmembrane transporter genes has eight known members in S. cerevisiae. ... All are putative anion:cationsymporters of vitamins (such as allantoate, nicotinate, panthotenate and biotin). The DAL5 subfamily is an old and important group since it is represented in both Basidiomycetes ("mushrooms") and Ascomycetes ("yeast"). We studied the complex evolution of this group in species from the kingdom of fungi particularly the Ascomycetes. Results: We identified numerousgene duplications creating sets of orthologous and paralogous genes. In different lineages the DAL5 subfamily members expanded or contracted and insome lineages a specific member could not be found at all. We also observed a close relationship between the gene YIL166C and its homologs in the Saccharomyces sensu stricto species and two "wine spoiler" yeasts, Dekkera bruxellensis and Candida guilliermondi, which could possibly be the result of horizontal gene transfer between these distantly related species. In the analyses we detect several well defined groups without S. cerevisiae representation suggesting new gene members in this subfamily with perhaps altered specialization or function. Conclusion: The transmembrane DAL5 subfamily was found to have a very complex evolution in yeast with intra- and interspecific duplications and unusual relationships indicating specialization, specific deletions and maybe even horizontal gene transfer. Webelieve that this group will be important in future investigations of evolution in fungi and especially the evolution of transmembrane proteins and their specialization.Vir: BMC genomics [Elektronski vir]. - ISSN 1471-2164 (Letn. 9, 2008, str. 164 [1-11])Vrsta gradiva - članek, sestavni delLeto - 2008Jezik - angleškiCOBISS.SI-ID - 25348569
Avtor
Hellborg, Linda |
Woolfit, Megan |
Arthursson-Helblborg, Mattias |
Piškur, Jure, 1960-2014
Teme
Evolution, Molecular |
Phylogeny |
Computational Biology |
Fungi |
Genetics |
Likelihood Functions |
Models, Genetic |
Multigene Family |
Genetics |
Species Specificity |
Filogeneza |
Evolucija molekularna |
Vrsta, specifičnost |
Mnogogenska družina |
Glive |
Verjetnostne funkcije |
Računalniška biologija |
Modeli genetski
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Hellborg, Linda | ![]() |
Woolfit, Megan | ![]() |
Arthursson-Helblborg, Mattias | ![]() |
Piškur, Jure, 1960-2014 | 31275 |
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