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  • Animal deoxyribonucleoside kinases : 'forward' and 'retrograde' evolution of their substrate specificity
    Piškur, Jure, 1960-2014 ...
    Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to ... study gene duplicationand specialisation of the duplicated copies through partitioning ofsubstrate specificity. Recent studies suggest that in the animal lineage oneof the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.
    Vir: FEBS letters. - ISSN 0014-5793 (Letn. 560, št. 1/3, 2004, str. 3-6)
    Vrsta gradiva - članek, sestavni del
    Leto - 2004
    Jezik - angleški
    COBISS.SI-ID - 25362137
    DOI

vir: FEBS letters. - ISSN 0014-5793 (Letn. 560, št. 1/3, 2004, str. 3-6)
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