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Horizontal gene transfer promoted evolution of the ability to propagate under anaerobic conditions in yeastsGojković, Zoran ...The ability to propagate under anaerobic conditions is an essential and uniquetrait of brewer's or baker's yeast ( Saccharomyces cervisiae). To understand the evolution of facultative anaerobiosis we ... studied the dependence of de novo pyrimidine biosynthesis, more precisely the fourth enzymic activity catalysed by dihydroorotate dehydrogenase (DHODase), on the enzymes of the respiratory chain in several yeast species. While the majority of yeasts possess a mitochondrial DHODase, Saccharomyces cerevisiae has a cytoplasmatic enzyme, whose activity is independent of the presence of oxygen.From the phylogenetic point of view, this enzyme is closely related toa bacterial DHODase from Lactococcus lactis. Here we show that S. kluyveri, which separated from the S. cerevisiae lineage more than 100 million years ago, represents an evolutionary intermediate, having both cytoplasmic and mitochondrial DHODases. We show that these two S. kluyveri enzymes, and their coding genes, differ in their dependence on the presence of oxygen. Only the cytoplasmic DHODase promotes growth in the absence of oxygen. Apparently a Saccharomyces yeast progenitor which had a eukaryotic-like mitochondrial DHODase acquired a bacterial gene for DHODase, which subsequently allowed cellgrowth gradually to become independent of oxygen.Vir: Molecular genetics and genomics : MGG. - ISSN 1617-4615 (Letn. 271, št. 4, 2004, str. 387-393)Vrsta gradiva - članek, sestavni delLeto - 2004Jezik - angleškiCOBISS.SI-ID - 25407193
Avtor
Gojković, Zoran |
Knecht, Wolfgang |
Zameitat, Elke |
Moller, Kasper |
Piškur, Jure, 1960-2014
Teme
Anaerobiosis |
Evolution |
Cell Division |
Cytoplasm |
Enzymology |
Dna, Fungal |
Genetics |
Isolation & Purification |
Electron Transport |
Mitochondria |
Enzymology |
Oxygen |
Metabolism |
Phylogeny |
Pyrimidines |
Biosynthesis |
Saccharomyces Cerevisiae |
Enzymology |
Genetics |
Growth & Development |
Subcellular Fractions |
Enzymology |
Evolucija |
Anaerobioza |
Filogeneza |
Saccharomyces cerevisiae |
Kisik |
Elektronski prenos |
Celična delitev |
DNA glivična |
Mitohondriji |
Subcelične frakcije |
Citoplazma |
Pirimidini
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Gojković, Zoran | ![]() |
Knecht, Wolfgang | ![]() |
Zameitat, Elke | ![]() |
Moller, Kasper | ![]() |
Piškur, Jure, 1960-2014 | 31275 |
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