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  • Plant dihydroorotate dehydrogenase differs significantly in substrate specificity and inhibition from the animal enzymes
    Ullrich, Alexandra ...
    The mitochondrial membrane bound dihydroorotate dehydrogenase (DHODH; EC 1.3.99.11) catalyzes the fourth step of pyrimidine biosynthesis. By the present correction of a known cDNA sequence for ... Arabidopsis thaliana DHODH we revealed the importance of the very C-terminal part for its catalytic activityand the reason why--in contrast to mammalian and insect species--the recombinant plant flavoenzyme was unaccessible to date for in vitro characterization. Structure-activity relationship studies explained that potent inhibitors of animal DHODH do not significantly affect the plant enzyme. These difference could be exploited for a novel approach to herb or pest growth control by limitation of pyrimidine nucleotide pools.
    Vir: FEBS letters. - ISSN 0014-5793 (Letn. 529, št. 2-3, 2002, str. 346-350)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - angleški
    COBISS.SI-ID - 25483737

vir: FEBS letters. - ISSN 0014-5793 (Letn. 529, št. 2-3, 2002, str. 346-350)
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