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Is chemotherapy necessary for premenopausal women with lower-risk node-positive, endocrine responsive breast cancer? : 10-year update of International Breast Cancer Study Group Trial 11-93Thürlimann, Beat, 1955- ...INTRODUCTION: International Breast Cancer Study Group (IBCSG) Trial 11-93 is the largest trial evaluating the role of the addition of chemotherapy to ovarian function suppression/ablation (OFS) and ... tamoxifen in premenopausal patients with endocrine-responsive early breast cancer. METHODS: IBCSG Trial 11-93 is a randomized trial comparing four cycles of adjuvant chemotherapy (AC: doxorubicin or epirubicin, plus cyclophosphamide) added to OFS and 5 years of tamoxifen versus OFS and tamoxifen without chemotherapy in premenopausal patients with node-positive, endocrine-responsive early breast cancer. There were 174 patients randomized from May 1993 to November 1998. The trial was closed before the target accrual was reached due to low accrual rate. RESULTS: Patients randomized tended to have lower risk node-positive disease and the median age was 45. After 10 years median follow up, there remains no difference between the two randomized treatment groups for disease-free (hazard ratio=1.02 (0.57-1.83); P=0.94) or overall survival (hazard ratio=0.97 (0.44-2.16); P=0.94). CONCLUSION: This trial, although small, offers no evidence that AC chemotherapy provides additional disease control for premenopausal patients with lower-risk node-positive endocrine-responsive breast cancer who receive adequate adjuvant endocrine therapy. A large trial is needed to determine whether chemotherapy adds benefit to endocrine therapy for this population.Vir: Breast cancer research and treatment [Elektronski vir]. - ISSN 1573-7217 (Letn. 113, št. 1, 2009, str. 137-144)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2009Jezik - angleškiCOBISS.SI-ID - 25795801
Avtor
Thürlimann, Beat, 1955- |
Price, Karen |
Gelber, Richard D.
Drugi avtorji
Lindtner, Jurij |
Eržen, Darja, 1952- |
Čufer, Tanja, 1955- |
Červek, Jožica |
Cerar, Olga |
Zakotnik, Branko |
Majdič, Elga |
Golouh, Rastko |
Lamovec, Janez |
Jančar, Janez, 1945- |
Vrhovec, Ivan, 1943- |
Kramberger, Marta
Teme
Breast Neoplasms |
Drug Therapy |
Mortality |
Chemotherapy, Adjuvant |
Cyclophosphamide |
Administration & Dosage |
Doxorubicin |
Administration & Dosage |
Epirubicin |
Administration & Dosage |
Follow-Up Studies |
Lymph Nodes |
Pathology |
Lymphatic Metastasis |
Premenopause |
Receptors, Estrogen |
Analysis |
Receptors, Progesterone |
Analysis |
Risk Assessment |
Survival Analysis |
Survivors |
Tamoxifen |
Therapeutic Use |
Tveganje, ocenjevanje |
Preživetje, analiza |
Kemoterapija pomožna |
Dojka, novotvorbe |
Epirubicin |
Bezgavke |
Tamoksifen |
Receptorji progesteronski |
Doksorubicin |
Sledilne študije |
Limfatična metastaza |
Preživeli |
Ciklofosfamid |
Premenopavza |
Receptorji estrogenski
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Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Thürlimann, Beat, 1955- | ![]() |
Price, Karen | ![]() |
Gelber, Richard D. | ![]() |
Lindtner, Jurij | 05278 |
Eržen, Darja, 1952- | 14441 |
Čufer, Tanja, 1955- | 12179 |
Červek, Jožica | 03289 |
Cerar, Olga | 15832 |
Zakotnik, Branko | 11747 |
Majdič, Elga | 08751 |
Golouh, Rastko | 02686 |
Lamovec, Janez | 04376 |
Jančar, Janez, 1945- | 09170 |
Vrhovec, Ivan, 1943- | 07195 |
Kramberger, Marta | 14442 |
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