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  • A study of midazolam plasma concentrations in patients undergoing conscius sedation
    Benedik, Janez ; Koželj, Gordana ; Manohin, Aleksander, 1946-202
    We studied midazolam plasma concentrations in patients undergoing middle ear surgery (MES) in local anesthesia and sedation. This study was based on the dinical measurement of the level of sedation ... and determination of the sedationdose of midazolam. For optimallevel of sedation for this type of surgery we suggest the midazolam plasma concentrations with median of 0.03 mg L -1 and range from 0.01-0.10 mg L -1. This can be contrasted to the other studies where considerably higher plasma concentrations of midazolam (0.2 mg L-1) were proposed (S. Michalk et al., Intens. Care Med. 1988, 15, 37-41). Despite low midazolam concentrations the level of sedation was adequate.
    Vir: Acta chimica slovenica. - ISSN 1318-0207 (Letn. 57, št. 1, 2010, str. 206-211)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 26760665

vir: Acta chimica slovenica. - ISSN 1318-0207 (Letn. 57, št. 1, 2010, str. 206-211)
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