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  • The influence of fetal sex and mother's smoking and parity on AFP and free beta-HCG concentrations in amniotic fluid of unaffected second trimester pregnancies
    Brajenović-Milić, Bojana ...
    Objective. The aim is to investigate the influence of motherćs smoking and parity and fetal sex on AFP and free beta-hCG in amniotic fluid and to examinethe correlation between maternal serum and ... amniotic fluid marker concentrations. Methods. The study was performed on 233 second-trimester amniotic fluid samples. In 75 women, blood sample was taken immediately beforeamniocentesis too. All pregnancies were singleton with normal fetal karyotype and outcome. Concentrations of AFP and free beta-hCG were determinedby fluoroimmunoassay and converted to MoM, according to medians for unaffected pregnancies of the corresponding gestational age. Results. In smoking women, amniotic fluid free beta-hCG was significantly lower than in non-smoking ones (p=0.033), though AFP was not significantly different in regard to smoking habits (p=0.113). Significantly higher amniotic fluid free beta-hCG (p<0.001) and lower AFP (p=0.015) were found in female, in comparisonto fetal male gender. No significant change according to parity, neither for free beta-hCG, nor for AFP was observed (p=0.094 and p=0.376, respectively). Significant correlation of AFP to free beta-hCG was found between serum and amniotic fluid samples (r=0.61, p<0.001 and r=0.35, p<0.002,respectively). Conclusions. Our results confirmed the influence of fetal sex on amniotic fluid AFP and free beta-hCG and negative influence of smoking on free beta-hCG as well as on maternal serum AFP and free beta-hCG concentrations. More data should be available to determine the impact of parity on examined amniotic fluid markers.
    Vir: Gynaecologia et Perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics. - ISSN 1330-0091 (Letn. 16, št. 1, 2007, str. 14-18)
    Vrsta gradiva - članek, sestavni del
    Leto - 2007
    Jezik - angleški
    COBISS.SI-ID - 26896857

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