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Letrozole therapy alone or in sequence with tamoxifen in women with breast cancerMouridsen, H. T. ...Background: The aromatase inhibitor letrozole, as compared with tamoxifen, improves disease-free survival among postmenopausal women with receptor-positive early breast cancer. It is unknown whether ... sequential treatment with tamoxifen and letrozole is superior to letrozole therapy alone.Methods: In this randomized, phase 3, double-blind trial of the treatment of hormone-receptor-positive breast cancer in postmenopausal women, we randomly assigned women to receive 5 years of tamoxifen monotherapy, 5 years of letrozole monotherapy, or 2 years of treatment with one agent followed by 3 years of treatment with the other. We compared the sequential treatments with letrozole monotherapy among 6182 women and also report a protocol-specified updated analysis of letrozole versus tamoxifen monotherapy in 4922 women. Results: At a median follow-up of 71 months after randomization, disease-free survival was not significantly improved with either sequential treatment as compared with letrozole alone (hazard ratio fortamoxifen followed by letrozole, 1.05; 99% confidence interval šCIđ, 0.84 to 1.32; hazard ratio for letrozole followed by tamoxifen, 0.96; 99% CI, 0.76 to 1.21). There were more early relapses among women who were assigned to tamoxifen followed by letrozole than among those who were assigned to letrozole alone. The updated analysis of monotherapy showed that there was a nonsignificant difference in overall survival between women assigned to treatment with letrozole and those assigned to treatment with tamoxifen (hazard ratio for letrozole, 0.87; 95% CI, 0.75 to 1.02; P=0.08). The rate of adverse events was as expected on the basis of previous reports of letrozole and tamoxifen therapy. Conclusions: Among postmenopausal women with endocrine-responsive breast cancer, sequential treatment with letrozole and tamoxifen, as compared with letrozole monotherapy, did not improve disease-free survival. (Abs. trunc. at 2000 ch.)Vir: The New England journal of medicine. - ISSN 0028-4793 (Letn. 361, št. 8, 2009, str. 766-776)Vrsta gradiva - članek, sestavni delLeto - 2009Jezik - angleškiCOBISS.SI-ID - 27359961
Avtor
Mouridsen, H. T. |
Giobbie-Hurber, Anita |
Goldhirsch, Aron |
Čufer, Tanja, 1955-
Teme
Antineoplastic Agents, Hormonal |
Administration & Dosage |
Adverse Effects |
Breast Neoplasms |
Drug Therapy |
Chemotherapy, Adjuvant |
Disease-Free Survival |
Double-Blind Method |
Drug Administration Schedule |
Follow-Up Studies |
Incidence |
Neoplasm Recurrence, Local |
Prevention & Control |
Nitriles |
Adverse Effects |
Administration & Dosage |
Postmenopause |
Proportional Hazards Models |
Tamoxifen |
Administration & Dosage |
Adverse Effects |
Triazoles |
Administration & Dosage |
Adverse Effects |
Dvojnoslepa metoda |
Proporcionalni modeli tveganja |
Triazoli |
Kemoterapija pomožna |
Brez bolezni, preživetje |
Incidenca |
Antineoplastiki hormonski |
Dojka, novotvorbe |
Tamoksifen |
Pomenopavza |
Zdravila, doziranje |
Sledilne študije |
Novotvorba, ponovitev lokalna |
Nitrili
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Mouridsen, H. T. | ![]() |
Giobbie-Hurber, Anita | ![]() |
Goldhirsch, Aron | ![]() |
Čufer, Tanja, 1955- | 12179 |
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