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  • The role of endothelin B receptor in bone modelling during orthodontic tooth movement [Elektronski vir] : a study on ET B knockout rats
    Disha Ibrahimi, Saranda ...
    The endothelin system has an important role in bone modelling during orthodontic tooth movement (OTM); however, little is known about the involvement of endothelin B receptors (ETB) in this process. ... The aim of this study was to evaluate the role of ETB in bone modelling during OTM using ETB knockout rats (ETB-KO). Thirty-two male rats were divided into 4 groups (n = 8 per group): the ETB-KO appliance group, ETB-KO control group, wild type (ETB-WT) appliance group, and ETB-WT control group. The appliance consisted of a super-elastic closed-coil spring placed between the first and second left maxillary molar and the incisors. Tooth movement was measured on days 0 and 35, and maxillary alveolar bone volume, osteoblast, and osteoclast volume were determined histomorphometrically on day 35 of OTM. Next, we determined the serum endothelin 1 (ET-1) level and gene expression levels of the osteoclast activity marker cathepsin K and osteoblast activity markers osteocalcin and dentin matrix acidic phosphoprotein 1 (DMP1) on day 35. The ETB-KO appliance group showed significantly lower osteoblast activity, diminished alveolar bone volume and less OTM than the ETB-WT appliance group. Our results showed that ETB is involved in bone modelling in the late stage of OTM.
    Vir: Scientific reports [Elektronski vir]. - ISSN 2045-2322 (Vol. 10, 2020, str. [1-11])
    Vrsta gradiva - e-članek
    Leto - 2020
    Jezik - angleški
    COBISS.SI-ID - 27363587

    Povezava(-e):

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450079/pdf/41598_2020_Article_71159.pdf
    Repozitorij Univerze v Ljubljani – RUL
    DOI

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